Results 151 to 160 of about 103,347 (189)
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Thiolation of Chitosan. Attachment of Proteins via Thioether Formation
Biomacromolecules, 2005Chitosan has a variety of biological functions through conjugating of other compounds to their amino and hydroxyl groups. To further expand applicability of chitosan, we have modified the amino group of chitosan with 2-iminothiolane to bestow thiol groups and obtained about 20% yield, which is equivalent to 913 microequiv SH/g chitosan or 457 nequiv SH/
Tatsuya, Masuko +5 more
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Preparation and evaluation of thiolated chitosan scaffolds for tissue engineering
Journal of Biomedical Materials Research Part A, 2009AbstractThiolated chitosan (TCS) was proposed as a promising candidate as scaffold material for tissue engineering. However, a continuous exploration of such material as a three‐dimensional (3D) scaffold with controllable design of microstructure as well as mechanical strength was necessitated.
Zhe, Li +5 more
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International Journal of Biological Macromolecules, 2017
Chitosan is a natural mucoadhesive, biodegradable, biocompatible and nontoxic polymer which has been used in pharmaceutical industry for a lot of purposes such as dissolution enhancing, absorption enhancing, sustained releasing and protein, gene or drug delivery.
Shirin, Hakimi +7 more
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Chitosan is a natural mucoadhesive, biodegradable, biocompatible and nontoxic polymer which has been used in pharmaceutical industry for a lot of purposes such as dissolution enhancing, absorption enhancing, sustained releasing and protein, gene or drug delivery.
Shirin, Hakimi +7 more
openaire +2 more sources
International Journal of Biological Macromolecules, 2019
Chitosan as a biopolymer is an attractive vehicle for biomedical applications due to its unique characteristics. In order to improve chitosan's physicochemical features, chemical modification has been carried out to make it more suitable for such approaches.
Mir Salar, Kazemi +6 more
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Chitosan as a biopolymer is an attractive vehicle for biomedical applications due to its unique characteristics. In order to improve chitosan's physicochemical features, chemical modification has been carried out to make it more suitable for such approaches.
Mir Salar, Kazemi +6 more
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In Vivo Evaluation of Thiolated Chitosan Tablets for Oral Insulin Delivery
Journal of Pharmaceutical Sciences, 2014Chitosan-6-mercaptonicotinic acid (chitosan-6-MNA) is a thiolated chitosan with strong mucoadhesive properties and a pH-independent reactivity. This study aimed to evaluate the in vivo potential for the oral delivery of insulin. The comparison of the nonconjugated chitosan and chitosan-6-MNA was performed on several studies such as mucoadhesion ...
Denise Schimek +2 more
exaly +3 more sources
Chitosan-4-mercaptobenzoic acid: synthesis and characterization of a novel thiolated chitosan
Journal of Materials Chemistry, 2010Thiomers are thiolated polymers with excellent mucoadhesive properties. The aim of this study was to synthesize a novel thiolated chitosan with higher reactivity in order to further improve mucoadhesion. For this purpose, 4-mercaptobenzoic acid was chosen to be covalently attached to chitosan.
Millotti, Gioconda +4 more
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Pharmaceutical Development and Technology, 2021
α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin (GP) crosslinking and the surface modification by Eudragit® L100 (L100). The particle
Wipada, Samprasit +2 more
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α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin (GP) crosslinking and the surface modification by Eudragit® L100 (L100). The particle
Wipada, Samprasit +2 more
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Journal of Microencapsulation, 2012
Probiotic bacteria were previously encapsulated in sub-100 µm Ca(2+) alginate microcapsules for enhanced survival in human gastrointestinal tract. The aim of this study is to evaluate the altered mucoadhesive property of the probiotic delivery system by coating it with mucoadhesive chitosan or thiolated chitosan, for prolonged retention in human colon.
Song, Chen +4 more
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Probiotic bacteria were previously encapsulated in sub-100 µm Ca(2+) alginate microcapsules for enhanced survival in human gastrointestinal tract. The aim of this study is to evaluate the altered mucoadhesive property of the probiotic delivery system by coating it with mucoadhesive chitosan or thiolated chitosan, for prolonged retention in human colon.
Song, Chen +4 more
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Preparation of novel thiolated chitosan with significant antioxidant activity
International Journal of Biological MacromoleculesThe aim of this study was to synthesize thiolated chitosan derivative and evaluated its antioxidant activity. Thiol groups were introduced into chitosan and hydroxypropyl trimethylammonium chloride chitosan quaternary ammonium salt (HACC) by microwave reaction, respectively.
Xiangru, Han +7 more
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Thiolated chitosan microparticles: A vehicle for nasal peptide drug delivery
International Journal of Pharmaceutics, 2006The goal of this study was to develop a microparticulate delivery system based on a thiolated chitosan conjugate for the nasal application of peptides. Insulin was used as model peptide. For thiolation of chitosan 2-iminothiolane was covalently linked to chitosan.
Alexander H, Krauland +2 more
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