Results 131 to 140 of about 7,079 (242)

Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase

, 2005
Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance treatment of childhood acute lymphoblastic leukaemia ...
openaire   +1 more source

Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment

Biomedicine & Pharmacotherapy
Understanding the molecular mechanisms of medicines is crucial for developing novel drugs, for repurposing existing medicines, and for predicting toxicities. Thiopurine S-methyltransferase (TPMT) serves as an exemplary case in personalized medicine, as its activity is influenced by genetic variants, co-factors, substrates, and inhibitors, which lead to
Dunja Urbančič, Marko Jukič, Alenka Šmid, Stanislav Gobec, Janez Jazbec, Irena Mlinarič-Raščan   +5 more
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Monitoring thiopurine methyltransferase (TPMT) activity in inflammatory bowel disease: is it worth it? [PDF]

, 2011
T Gledhill, A HURST, Laurie Brown, Philip Bliss   +3 more
openalex   +1 more source

Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait. [PDF]

Clin Pharmacol Ther, 2017
Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV.   +21 more
europepmc   +1 more source

Genetic polymorphism of thiopurine S-methyltransferase in Argentina [PDF]

, 2003
Laura E. Laróvere, Raquel Dodelson de Kremer, L. H. J. Lambooy, Ronney A. De Abreu   +3 more
openalex   +1 more source

[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].

Anales de pediatria (Barcelona, Spain : 2003), 2009
Individualised doses of azathioprine (AZA) may be prescribed by monitoring the levels of the enzyme thiopurine methyltransferase (TPMT). The measurements of thiopurine metabolites of AZA, 6-thioguanine (6-TGN) and 6-methylmercaptopurine (6-MMP), have also been reported as new markers of AZA activity.To describe TPMT phenotype in our population and to ...
M, Alvarez Beltran, D, Infante Pina, R, Tormo Carnicé, O, Segarra Cantón, S, Redecillas Ferreiro   +4 more
openaire   +1 more source

P-176 Thiopurine S-methyltransferase Analysis Does Not Correctly Predict the Risk of Toxicity in Hispanic Children with Inflammatory Bowel Disease [PDF]

, 2013
Jubin Mathews, Lina Castillo, Jesse Reeves‐Garcia, Richard Arboleda, Roberto Gomara, William I. Muinos, Erick Hernandez   +6 more
openalex   +1 more source

Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus [PDF]

, 2013

core   +1 more source

Integration of a standardized pharmacogenomic platform for clinical decision support at Boston Children's Hospital [PDF]

, 2012
Brownstein, Catherine A., Clinton, Catherine, Fusaro, Vincent Alfred, Mandl, Kenneth David, Manzi, Shannon, Margulies, David Michael, Savage, Sarah, Wolf, Wendy   +7 more
core   +1 more source

Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase [PDF]

, 2005
M Konstantopoulou, A Belgi, K. Griffiths, Jim Seale, A.W. MACFARLANE   +4 more
openalex   +1 more source