Results 131 to 140 of about 6,964 (243)

Monitoring thiopurine methyltransferase (TPMT) activity in inflammatory bowel disease: is it worth it? [PDF]

, 2011
T Gledhill, A HURST, Laurie Brown, Philip Bliss   +3 more
openalex   +1 more source

Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase

, 2005
Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance treatment of childhood acute lymphoblastic leukaemia ...
openaire   +1 more source

S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts

, 2009
Miha Milek, Nataša Karas Kuželički, Alenka Šmid, Irena Mlinarič‐Raščan   +3 more
openalex   +2 more sources

Genotyping of Eight Thiopurine Methyltransferase Mutations: Three-Color Multiplexing, “Two-Color/Shared” Anchor, and Fluorescence-quenching Hybridization Probe Assays Based on Thermodynamic Nearest-Neighbor Probe Design [PDF]

, 2000
Ekkehard Schütz, Nicolas von Ahsen, Michael Oellerich   +2 more
openalex   +1 more source

Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait. [PDF]

Clin Pharmacol Ther, 2017
Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV.   +21 more
europepmc   +1 more source

P-176 Thiopurine S-methyltransferase Analysis Does Not Correctly Predict the Risk of Toxicity in Hispanic Children with Inflammatory Bowel Disease [PDF]

, 2013
Jubin Mathews, Lina Castillo, Jesse Reeves‐Garcia, Richard Arboleda, Roberto Gomara, William I. Muinos, Erick Hernandez   +6 more
openalex   +1 more source

Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus [PDF]

, 2013

core   +1 more source

Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase [PDF]

, 2005
M Konstantopoulou, A Belgi, K. Griffiths, Jim Seale, A.W. MACFARLANE   +4 more
openalex   +1 more source

Integration of a standardized pharmacogenomic platform for clinical decision support at Boston Children's Hospital [PDF]

, 2012
Brownstein, Catherine A., Clinton, Catherine, Fusaro, Vincent Alfred, Mandl, Kenneth David, Manzi, Shannon, Margulies, David Michael, Savage, Sarah, Wolf, Wendy   +7 more
core   +1 more source

Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients [PDF]

, 2017
Minseok Lee, Jimyung Seo, Dongsik Bang, Do Young ‍Kim   +3 more
openalex   +1 more source