Results 181 to 190 of about 10,789 (224)

Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S‐methyltransferase inhibition

Journal of Gastroenterology and Hepatology, 2021
AbstractBackground and AimThiopurines are often used in combination with mesalazine for the treatment of ulcerative colitis (UC). Mesalazine formulations are delivered to the digestive tract by various delivery systems and absorbed as 5‐aminosalicylic acid (5‐ASA).
Hiromu Morikubo, Taku Kobayashi, Ryo Ozaki, Shinji Okabayashi, Satoshi Kuronuma, Osamu Takeuchi, Tenyo Shiba, Hiroki Kiyohara, Mao Matsubayashi, Shintaro Sagami, Masaru Nakano, Osamu Ikezaki, Tadakazu Hisamatsu, Yoichi Tanaka, Toshifumi Hibi   +14 more
openaire   +2 more sources

The Future of Thiopurine Pharmacogenomics

Pharmacogenomics, 2012
Since their invention [1], thiopurines (azathioprine, 6-mercaptopurine [6MP], and 6-thioguanine [6TG]) have significantly advanced the treatment of acute lymphoblastic leukemia, organ transplantation, inflammatory bowel disease (IBD) and various autoimmune diseases.
Duley, John A., Somogyi, Andrew A., Martin, Jennifer H.   +2 more
openaire   +3 more sources

Reducing risk in thiopurine therapy

Xenobiotica, 2019
The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of disorders of immune regulation and acute lymphoblastic leukaemia. Although developed in the 1950s, thiopurines remained relevant in the anti-tumour necrosis factor biologic era, finding widespread use as a co-immunomodulator.
Anthony M, Marinaki, Monica, Arenas-Hernandez   +1 more
openaire   +2 more sources

Are Thiopurines Always Contraindicated After Thiopurine‐Induced Pancreatitis in Inflammatory Bowel Disease?

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACT Background and Aims: Thiopurine use in inflammatory bowel disease (IBD) is well established for maintenance of disease remission. Approximately 3% of patients with IBD develop thiopurine‐induced pancreatitis (TIP) as an idiosyncratic reaction.
Oren D, Ledder, Daniel A, Lemberg, Chee Y, Ooi, Andrew S, Day   +3 more
openaire   +2 more sources

Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy

Clinical Biochemistry, 2004
Standardization of thiopurine metabolite testing is currently lacking. This paper presents in-depth methodological analysis and optimization of two currently available HPLC procedures (Lennard-Singleton [J. Chromatogr. 583 (1992) 83] and Dervieux-Boulieu [Clin. Chem.
Cristiana, Stefan, Warren, Walsh, Tibor, Banka, Khosrow, Adeli, Zulfikarali, Verjee   +4 more
openaire   +2 more sources

Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
openaire   +2 more sources

No Induction of Thiopurine Methyltransferase During Thiopurine Treatment in Inflammatory Bowel Disease

Nucleosides, Nucleotides and Nucleic Acids, 2006
The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist, U, Hindorf, S, Almer, P, Söderkvist, M, Ström, H, Hjortswang, C, Peterson   +6 more
openaire   +2 more sources

Serious Infections in Children Born to Mothers With Inflammatory Bowel Disease With In Utero Exposure to Thiopurines and Anti-Tumor Necrosis Factor

Clinical Gastroenterology and Hepatology, 2022
Antoine Meyer, JEROME Drouin, Alain Weill   +2 more
exaly  

Intrauterine exposure to thiopurines

Reproductive Toxicology, 2012
Jharap, B., Seinen, M.L., van Bodegraven, A.A., de Boer, K.H.N.   +3 more
openaire   +3 more sources

Thiopurines

2010
Terreia S. Jones, Mary V. Relling
openaire   +1 more source