Results 181 to 190 of about 7,935 (218)

No Induction of Thiopurine Methyltransferase During Thiopurine Treatment in Inflammatory Bowel Disease

Nucleosides, Nucleotides and Nucleic Acids, 2006
The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist, U, Hindorf, S, Almer, P, Söderkvist, M, Ström, H, Hjortswang, C, Peterson   +6 more
openaire   +2 more sources

Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy

Clinical Biochemistry, 2004
Standardization of thiopurine metabolite testing is currently lacking. This paper presents in-depth methodological analysis and optimization of two currently available HPLC procedures (Lennard-Singleton [J. Chromatogr. 583 (1992) 83] and Dervieux-Boulieu [Clin. Chem.
Cristiana, Stefan, Warren, Walsh, Tibor, Banka, Khosrow, Adeli, Zulfikarali, Verjee   +4 more
openaire   +2 more sources

Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis

Journal of Hepatology, 2010
Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT) as well as thioguanine nucleotide (TGN) and ...
Ulf, Hindorf, Khatoon, Jahed, Annika, Bergquist, Hans, Verbaan, Hanne, Prytz, Sven, Wallerstedt, Mårten, Werner, Rolf, Olsson, Einar, Björnsson, Curt, Peterson, Sven H C, Almer   +10 more
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Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
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Reducing risk in thiopurine therapy

Xenobiotica, 2019
The thiopurine drugs azathioprine and mercaptopurine are effective in the treatment of disorders of immune regulation and acute lymphoblastic leukaemia. Although developed in the 1950s, thiopurines remained relevant in the anti-tumour necrosis factor biologic era, finding widespread use as a co-immunomodulator.
Anthony M, Marinaki, Monica, Arenas-Hernandez   +1 more
openaire   +2 more sources

Clinical pharmacology and pharmacogenetics of thiopurines

European Journal of Clinical Pharmacology, 2008
The thiopurine drugs-azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine-are widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. However, thiopurine drugs have a relatively narrow therapeutic index and are capable of causing life-threatening toxicity,
Srikumar, Sahasranaman, Danny, Howard, Sandip, Roy   +2 more
openaire   +2 more sources

On the malignant potential of thiopurine therapy

Blood, 2009
To the editor: With great interest we have read the paper by Schmiegelow and colleagues describing the increased risk of developing a second malignant neoplasm, especially acute myeloid leukemia and myelodysplastic syndromes, due to maintenance therapy with 6-mercaptopurine (6-MP) and ...
de Boer, N., van Asseldonk, D.P., van Bodegraven, A.A.   +2 more
openaire   +4 more sources

Thiopurine therapy

European Journal of Gastroenterology & Hepatology, 2003
The thiopurines azathioprine and 6-mercaptopurine are effective both for active disease and for maintaining remission in both Crohn's disease and ulcerative colitis. This review describes criteria for starting thiopurines (two or more courses of steroids in a calendar year, relapse as prednisolone is reduced below 15 mg/day, within 6 weeks of stopping ...
Dermot P B, McGovern, Simon P L, Travis
openaire   +2 more sources

Low-dose thiopurine with allopurinol co-therapy overcomes thiopurine intolerance and allows thiopurine continuation in inflammatory bowel disease

Digestive and Liver Disease, 2018
To assess the utility and tolerability of thiopurine-allopurinol co-therapy in inflammatory bowel disease (IBD) patients with intolerance to thiopurine monotherapy.A retrospective observational study assessed cases of thiopurine intolerance then switched to thiopurine allopurinol co-therapy between 2011 and 2015 at two centres.
Abhinav Vasudevan, Lauren Beswick, Antony B. Friedman, Alicia Moltzen, James Haridy, Ajay Raghunath, Miles Sparrow, Daniel van Langenberg   +7 more
openaire   +2 more sources

Methods for the Synthesis of 6‐Thiopurines

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source