Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity
Antioxidants, 2023 Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda +1 more
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The over expression of thioredoxin during malignancies [PDF]
Reviews in Clinical Medicine, 2014 Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells.
Shahaboddin Shabani +2 more
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JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. [PDF]
PLoS ONE, 2010 The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting
Kornelia Edes +3 more
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Fluorogenic probes for thioredoxin reductase activity
Results in Chemistry, 2021 The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH.
Tendai J. Mafireyi +2 more
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The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition. [PDF]
PLoS ONE, 2016 BACKGROUND:The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is
Kathrin Reiser +9 more
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Tissue Distribution and Activity of Thioredoxin Reductase in Pancreatic Carcinoma [PDF]
Middle East Journal of Cancer, 2019 Background: Thioredoxin, NADPH, and thioredoxin reductase form the thioredoxinsystem which exists in all living cells. Oxidants have a major role in cancer pathogenesis;therefore, it is necessary to study the role of redox-active compounds such as ...
Faezeh Sadrabadi Haghighi +3 more
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Effect of thioredoxin on the immunogenicity of the recombinant P32 protein of lumpy skin disease virus [PDF]
Veterinary World, 2022 Background and Aim: The rapid spread of lumpy skin disease (LSD) globally poses a serious threat to the agricultural sector. The timely and accurate diagnosis of the disease is crucial to control LSD.
Kanat Tursunov +4 more
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Assessment of salivary thioredoxin levels in oral lichen planus and oral squamous cell carcinoma
Clinical and Experimental Dental Research, 2021 Objective Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, which is considered as a potentially malignant condition and could transformed into oral squamous cell carcinoma (OSCC).
Maryam Amirchaghmaghi +5 more
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Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. [PDF]
PLoS ONE, 2013 BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by acute enhancement of airway neutrophilic inflammation under oxidative stress and can be involved in emphysema progression. However, pharmacotherapy against the
Naoya Tanabe +10 more
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Haematologica, 2007 Background and Objectives The redox-regulatory protein thioredoxin has several functions including transcriptional regulation, and antioxidant, cytokine, and chemokine activities.
Eva Bäckman +8 more
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