Results 11 to 20 of about 19,795 (176)

Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci)

Journal of Parasitology Research, 2010
Mitochondrial thioredoxin-glutathione reductase was purified from larval Taenia crassiceps (cysticerci). The preparation showed NADPH-dependent reductase activity with either thioredoxin or GSSG, and was able to perform thiol/disulfide exchange reactions.
Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón   +5 more
doaj   +2 more sources

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Cell Reports, 2017
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively ...
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt   +16 more
doaj   +2 more sources

Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins [PDF]

Cell Reports, 2014
Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol.
Marco Pirazzini, Domenico Azarnia Tehran, Giulia Zanetti, Aram Megighian, Michele Scorzeto, Silvia Fillo, Clifford C. Shone, Thomas Binz, Ornella Rossetto, Florigio Lista, Cesare Montecucco   +10 more
doaj   +2 more sources

Differential expression of disulfide reductase enzymes in a free-living platyhelminth (Dugesia dorotocephala).

PLoS ONE, 2017
A search of the disulfide reductase activities expressed in the adult stage of the free-living platyhelminth Dugesia dorotocephala was carried out. Using GSSG or DTNB as substrates, it was possible to obtain a purified fraction containing both GSSG and ...
Alberto Guevara-Flores, Álvaro Miguel Herrera-Juárez, José de Jesús Martínez-González, Irene Patricia Del Arenal Mena, Óscar Flores-Herrera, Juan Luis Rendón   +5 more
doaj   +2 more sources

A Rare Case of Coexisting Mutation in Desmin and Thioredoxin Reductase 2 Genes Causing Dilated Cardiomyopathy [PDF]

, 2023
Desmin (DES) maintains the overall structure of cardiomyocytes and cytoskeletal organization within striated muscle cells. Mitochondrial thioredoxin reductase 2 (TXNRD-2) is essential for mitochondrial oxygen radical scavenging.
Khatun, Nazima, Salciccioli, Louis, Zaveri, Sahil, John, Sabu   +3 more
core   +1 more source

Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. [PDF]

PLoS ONE, 2012
Thioredoxin glutathione reductase (TGR) is a member of the mammalian thioredoxin reductase family that has a monothiol glutaredoxin (Grx) domain attached to the thioredoxin reductase module.
Olena Dobrovolska, Elena Shumilina, Vadim N Gladyshev, Alexander Dikiy   +3 more
doaj   +1 more source

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]

PLoS Pathogens, 2016
Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin, Kathryn M O'Brien, Carolina Trujillo, Ruojun Wang, Joshua B Wallach, Dirk Schnappinger, Sabine Ehrt   +6 more
doaj   +1 more source

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]

PLoS ONE, 2008
BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål, Stefanie Prast-Nielsen, Narimantas Cenas, Elias S J Arnér   +3 more
doaj   +1 more source

Thioredoxin Dependent Changes in the Redox States of FurA from Anabaena sp. PCC 7120

Antioxidants, 2021
FurA is a multifunctional regulator in cyanobacteria that contains five cysteines, four of them arranged into two CXXC motifs. Lack of a structural zinc ion enables FurA to develop disulfide reductase activity.
Jorge Guío, María Teresa Bes, Mónica Balsera, Laura Calvo-Begueria, Emma Sevilla, María Luisa Peleato, María F. Fillat   +6 more
doaj   +1 more source

The role of thioredoxin reductases in brain development [PDF]

, 2008
The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we studied the roles of thioredoxin reductases in brain using mice with nervous system (NS ...
Jonna Soerensen, Schmidt, Jörg, Soerensen, Jonna, Markus Brielmeier, Schweizer, Ulrich, Schmahl, W., Schweizer, U., Jakupoglu, Cemile, Brielmeier, Markus, Heike Beck, Schmahl, Wolfgang W., Marcus Conrad, Conrad, M., Jörg Schmidt, Brielmeier, M., Förster, Heidi, Conrad, Marcus, Förster, H., Beck, H., Wolfgang Schmahl, Beck, Heike, Jakupoglu, C., Cemile Jakupoglu, Soerensen, J., Heidi Förster, Ulrich Schweizer, Schmidt, J.   +26 more
core   +1 more source