Results 11 to 20 of about 14,349 (139)

Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]

PLoS Pathogens, 2016
Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin, Kathryn M O'Brien, Carolina Trujillo, Ruojun Wang, Joshua B Wallach, Dirk Schnappinger, Sabine Ehrt   +6 more
doaj   +1 more source

Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]

PLoS ONE, 2008
BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål, Stefanie Prast-Nielsen, Narimantas Cenas, Elias S J Arnér   +3 more
doaj   +1 more source

Thioredoxin Dependent Changes in the Redox States of FurA from Anabaena sp. PCC 7120

Antioxidants, 2021
FurA is a multifunctional regulator in cyanobacteria that contains five cysteines, four of them arranged into two CXXC motifs. Lack of a structural zinc ion enables FurA to develop disulfide reductase activity.
Jorge Guío, María Teresa Bes, Mónica Balsera, Laura Calvo-Begueria, Emma Sevilla, María Luisa Peleato, María F. Fillat   +6 more
doaj   +1 more source

Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins

Cell Reports, 2014
Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol.
Marco Pirazzini, Domenico Azarnia Tehran, Giulia Zanetti, Aram Megighian, Michele Scorzeto, Silvia Fillo, Clifford C. Shone, Thomas Binz, Ornella Rossetto, Florigio Lista, Cesare Montecucco   +10 more
doaj   +1 more source

Differential expression of disulfide reductase enzymes in a free-living platyhelminth (Dugesia dorotocephala).

PLoS ONE, 2017
A search of the disulfide reductase activities expressed in the adult stage of the free-living platyhelminth Dugesia dorotocephala was carried out. Using GSSG or DTNB as substrates, it was possible to obtain a purified fraction containing both GSSG and ...
Alberto Guevara-Flores, Álvaro Miguel Herrera-Juárez, José de Jesús Martínez-González, Irene Patricia Del Arenal Mena, Óscar Flores-Herrera, Juan Luis Rendón   +5 more
doaj   +1 more source

Exploring the Diversity of the Thioredoxin Systems in Cyanobacteria

Antioxidants, 2022
Cyanobacteria evolved the ability to perform oxygenic photosynthesis using light energy to reduce CO2 from electrons extracted from water and form nutrients.
Manuel J. Mallén-Ponce, María José Huertas, Francisco J. Florencio   +2 more
doaj   +1 more source

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Cell Reports, 2017
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively ...
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt   +16 more
doaj   +1 more source

FRET-based system for probing protein-protein interactions between σR and RsrA from Streptomyces coelicolor in response to the redox environment. [PDF]

PLoS ONE, 2014
Protein-protein interactions between sigma factor σ(R) and its corresponding zinc-binding anti-sigma (ZAS) protein RsrA trigger the thioredoxin system for maintaining cellular redox homeostasis in S. coelicolor.
Zi-Han Wei, Huan Chen, Chang Zhang, Bang-Ce Ye   +3 more
doaj   +1 more source

Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci)

Journal of Parasitology Research, 2010
Mitochondrial thioredoxin-glutathione reductase was purified from larval Taenia crassiceps (cysticerci). The preparation showed NADPH-dependent reductase activity with either thioredoxin or GSSG, and was able to perform thiol/disulfide exchange reactions.
Alberto Guevara-Flores, Irene P. del Arenal, Guillermo Mendoza-Hernández, Juan Pablo Pardo, Oscar Flores-Herrera, Juan L. Rendón   +5 more
doaj   +1 more source

The Barley Grain Thioredoxin System – an Update

Frontiers in Plant Science, 2013
Thioredoxin reduces disulfide bonds and play numerous important functions in plants. In cereal seeds, cytosolic h-type thioredoxin facilitates the release of energy reserves during the germination process and is recycled by NADPH-dependent thioredoxin ...
Per eHägglund, Olof eBjörnberg, Nicolas eNavrot, Johanne eMørch Jensen, Kenji eMaeda, Kristine eKirkensgaard, Azar eShahpiri, Abida eSultan, Jakob eBunkenborg, Frank eGubler, José Maria Barrero, Anette eHenriksen, Christine eFinnie, Birte eSvensson   +13 more
doaj   +1 more source