Results 41 to 50 of about 19,795 (176)

Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. [PDF]

PLoS ONE, 2010
Spx, an ArsC (arsenate reductase) family member, is a global transcriptional regulator of the microbial stress response and is highly conserved amongst Gram-positive bacteria.
Michiko M Nakano, Ann Lin, Cole S Zuber, Kate J Newberry, Richard G Brennan, Peter Zuber   +5 more
doaj   +1 more source

Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically

, 2022
The cyclic five-membered disulfide 1,2-dithiolane has been used as the key element in numerous chemical biology probes. Contradictory views of this disulfide populate the literature: some reports describe it as being nonspecifically reduced, others as a ...
Sander, Busker, Christina, Brandstädter, Lena, Poczka, Katja, Becker, Oliver, Thorn-Seshold, Karoline, Scholzen, Ulrike, Theisen, Elias, Arnér, Martin S., Maier, Julia, Ahlfeld, Jan, Felber, Lukas, Zeisel   +11 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis

, 2007
Arsenic compounds commonly exist in nature and are toxic to nearly all kinds of life forms, which directed the evolution of enzymes in many organisms for arsenic detoxification.
Hu, Yunfei, Xia, Bin, Jin, Changwen, Xu, Huimin, Zhang, Xinxin, Lescop, Ewen, Li, You   +6 more
core   +1 more source

CBSX2 is required for the efficient oxidation of chloroplast redox‐regulated enzymes in darkness

Plant Direct, 2023
Thiol/disulfide‐based redox regulation in plant chloroplasts is essential for controlling the activity of target proteins in response to light signals.
Yonghong Li, Lin Zhang, Yurou Shen, Lianwei Peng, Fudan Gao   +4 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Characterisation of the oxidoreductase Erol-Lß and the misfolding of the secretory pathway substrate HLA-B27 [PDF]

, 2007
The endoplasmic reticulum (ER) is the site of oxidative folding for proteins entering the secretory pathway. Here, nascent polypeptides acquire disulfide bonds, which confer both stability and functionality on secretory and ER-resident proteins.
Lemin, Andrew James
core  

NK-lysin, a Disulfide-containing Effector Peptide of T-lymphocytes, Is Reduced and Inactivated by Human Thioredoxin Reductase

, 1996
The cytotoxic and antibacterial polypeptide NK-lysin has a molecular mass of approximately 9 kDa and contains three disulfide bonds. The activity was highly dependent on intact disulfides, because the bactericidal effect on Escherichia coli and the ...
Holmgren, A,, Arne Holmgren, Andersson, M,, Spyrou, G, Holmgren, A.,, Spyrou, Giannis,, Giannis Spyrou, Mats Andersson, Andersson, M.,   +8 more
core   +1 more source

Multiple functions of Nm23-H1 are regulated by oxido-reduction system. [PDF]

PLoS ONE, 2009
Nucleoside diphosphate kinase (NDPK, Nm23), a housekeeping enzyme, is known to be a multifunctional protein, acting as a metastasis suppressor, transactivation activity on c-myc, and regulating endocytosis.
Eunsun Lee, Jaeho Jeong, Sung Eun Kim, Eun Joo Song, Sang Won Kang, Kong-Joo Lee   +5 more
doaj   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source