Results 31 to 40 of about 19,795 (176)

Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

Cell Reports, 2022
Summary: Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action.
Fraser D. Johnson, John Ferrarone, Alvin Liu, Christina Brandstädter, Ravi Munuganti, Dylan A. Farnsworth, Daniel Lu, Jennifer Luu, Tianna Sihota, Sophie Jansen, Amy Nagelberg, Rocky Shi, Giovanni C. Forcina, Xu Zhang, Grace S.W. Cheng, Sandra E. Spencer Miko, Georgia de Rappard-Yuswack, Poul H. Sorensen, Scott J. Dixon, Udayan Guha, Katja Becker, Hakim Djaballah, Romel Somwar, Harold Varmus, Gregg B. Morin, William W. Lockwood   +25 more
doaj   +1 more source

Identification of Multiple Soluble Fe(III) Reductases in Gram-Positive Thermophilic Bacterium Thermoanaerobacter indiensis BSB-33

International Journal of Genomics, 2014
Thermoanaerobacter indiensis BSB-33 has been earlier shown to reduce Fe(III) and Cr(VI) anaerobically at 60°C optimally. Further, the Gram-positive thermophilic bacterium contains Cr(VI) reduction activity in both the membrane and cytoplasm.
Subrata Pal
doaj   +1 more source

Comparative molecular modeling study of Arabidopsis NADPH-dependent thioredoxin reductase and its hybrid protein. [PDF]

PLoS ONE, 2012
2-Cys peroxiredoxins (Prxs) play important roles in the protection of chloroplast proteins from oxidative damage. Arabidopsis NADPH-dependent thioredoxin reductase isotype C (AtNTRC) was identified as efficient electron donor for chloroplastic 2-Cys Prx ...
Yuno Lee, Songmi Kim, Prettina Lazar, Jeong Chan Moon, Swan Hwang, Sundarapandian Thangapandian, Youngsik Shon, Kyun Oh Lee, Sang Yeol Lee, Keun Woo Lee   +9 more
doaj   +1 more source

The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more [PDF]

, 2012
Significance: The oxidative process of disulfide-bond formation is essential for the folding of most secretory and membrane proteins in the endoplasmic reticulum (ER).
Ramming, Thomas, Appenzeller-Herzog, Christian   +1 more
core   +1 more source

The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin

Вавиловский журнал генетики и селекции, 2023
The milk-clotting enzyme chymosin is a member of the group of aspartate proteinases. Chymosin is the main component of rennet traditionally obtained from the stomachs of dairy calves and widely used to coagulate milk in the production of various types of
S. V. Belenkaya, D. N. Shcherbakov, A. I. Chapoval, T. I. Esina, V. V. Elchaninov   +4 more
doaj   +1 more source

Protein disulfide isomerase activity is essential for viability and extracellular matrix formation in the nematode Caenorhabditis elegans. [PDF]

, 2007
Protein disulfide isomerase (PDI) is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum.
Page, Antony P., McCormack, Gillian, Winter, AD, Page, AP, McCormack, G, Winter, Alan D.   +5 more
core   +1 more source

Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea

Antioxidants, 2020
To fight reactive oxygen species (ROS) produced by both the metabolism and strongly oxidative habitats, hyperthermophilic archaea are equipped with an array of antioxidant enzymes whose role is to protect the biological macromolecules from oxidative ...
Emilia Pedone, Gabriella Fiorentino, Simonetta Bartolucci, Danila Limauro   +3 more
doaj   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Brigelius-Flohé, Regina, Böck, August, Meyer, Ortwin   +5 more
core   +1 more source

Methylglyoxal Causes Dysfunction of Thioredoxin and Thioredoxin Reductase in Endothelial Cells

Journal of Pharmacological Sciences, 2009
Methylglyoxal (MG), a reactive dicarbonyl produced during glucose metabolism, induces oxidative stress and apoptosis. Under hyperglycemic conditions, the abnormal accumulation of MG is related to the development of diabetic complications. We examined the
Ryosuke Tatsunami, Tatsuya Oba, Kyohei Takahashi, Yoshiko Tampo   +3 more
doaj   +1 more source

Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide

Biomolecules, 2017
QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in the biosynthetic pathway to the tRNA modified nucleoside ...
Adeba Mohammad, Adriana Bon Ramos, Bobby W. K. Lee, Spencer W. Cohen, Maryam K. Kiani, Dirk Iwata-Reuyl, Boguslaw Stec, Manal A. Swairjo   +7 more
doaj   +1 more source