Results 121 to 130 of about 17,263,040 (272)
Phytotherapy Research, EarlyView.Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia +6 more
wiley +1 more source
The thioredoxin-1 (Trx1) system is an important cytoplasmic protein and is essential for maintaining neuronal redox homeostasis. Reduced Trx1 regulates the redox status of a wide range of proteins using two available electrons from its active sites.
Olanipekun, Tobi
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Phytotherapy Research, EarlyView.This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren +10 more
wiley +1 more source
Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential
Phytotherapy Research, EarlyView.Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.CA directly binds to and activates AMPK to suppress NLRP3/GSDMD signaling, thereby alleviating hepatocyte pyroptosis in T2DM mice. ABSTRACT Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage.
Huaiying Tang +13 more
wiley +1 more source
Impact of sleep insufficiency and recovery on cancer development
Sleep Research, EarlyView.Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley +1 more source
SusMat, EarlyView.This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang +12 more
wiley +1 more source
The thioredoxin system under intermittent hypoxia in cancer cells
, 2012 The oxygen environment is an important determinant of carcinogenesis. Cancer cells are mostly in flux between low and high oxygen availability, experiencing cycling between hypoxia and reoxygenation, a phenomenon termed as intermittent hypoxia.
Di Trapani, Jenny +3 more
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Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation
Integrative Zoology, EarlyView.Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv +4 more
wiley +1 more source
, 2001 Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system.
Jung, J K +7 more
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