Results 111 to 120 of about 169,438 (276)

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission [PDF]

, 2009
1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp.
Vega-Rodríguez Joel, Franke-Fayard Blandine, Coppens Isabelle, Waters Andrew P., Dinglasan, R.R., Andrew P. Waters, Joel Vega-Rodríguez, Rhoel R. Dinglasan, Jacobs-Lorena Marcelo, José F Rodríguez-Orengo, Jacobs-Lorena, M., Rodríguez-Orengo José F., Blandine Franke-Fayard, Chris J. Janse, Vega-Rodriguez, J., Isabelle Coppens, José F. Rodríguez-Orengo, Serrano Adelfa E., Adelfa E. Serrano, Janse, C.J., Serrano, A.E., Rhoel R Dinglasan, Prakash Srinivasan, Waters, A., Adelfa E Serrano, Marcelo Jacobs-Lorena, Pastrana-Mena Rebecca, Janse Chris J., Chris J Janse, Dinglasan Rhoel R., Rodriguez-Orengo, J.F., Srinivasan, P., Pastrana-Mena, R., Rebecca Pastrana-Mena, Franke-Fayard, B., Andrew P Waters   +35 more
core   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.

PLoS ONE, 2013
Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention of cell death.
Min-Hyuk Yoo, Bradley A Carlson, Vadim N Gladyshev, Dolph L Hatfield   +3 more
doaj   +1 more source

Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment

, 2016
As essential elements of the tumor microenvironment, the variable oxygenation state of the tumor tissue, the extracellular matrix (ECM) and different cell types are important determinants of carcinogenesis.
Tonissen, K. F., Prahlad V. Raninga, Tonissen, Kathryn F, Tonissen, Kathryn, Raninga, Prahlad, Lovitt, Carrie J, Avery, Vicky M, Raninga, P. V., Bhatia, Maneet, Avery, Vicky, Di Trapani, Giovanna, Di Trapani, Jenny, Di Trapani, G., Vicky M. Avery, Carrie J. Lovitt, Lovitt, Carrie, Maneet Bhatia, Raninga, Prahlad V, Avery, V. M., Lovitt, C. J., Kathryn F. Tonissen, Giovanna Di Trapani, Bhatia, M.   +22 more
core   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Brigelius-Flohé, Regina, Böck, August, Meyer, Ortwin   +5 more
core   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, EarlyView.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Role of thioredoxin reductase (TrxB) in oxidative stress response of Francisella tularensis live vaccine strain

Journal of Bacteriology
Francisella tularensis is an important human pathogen responsible for causing tularemia in the Northern Hemisphere. Francisella has been developed as a biological weapon in the past due to its extremely high virulence. F.
Matthew Higgs, Zhuo Ma, Anthony Centone, Chandra Shekhar Bakshi, Meenakshi Malik   +4 more
doaj   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Thiol/Disulfide system plays a crucial role in redox protection in the acidophilic iron-oxidizing bacterium Leptospirillum ferriphilum.

PLoS ONE, 2012
Thiol/disulfide systems are involved in the maintenance of the redox status of proteins and other molecules that contain thiol/disulfide groups. Leptospirillum ferriphilum DSM14647, an acidophilic bacterium that uses Fe(2+) as electron donor, and ...
Javiera Norambuena, Rodrigo Flores, Juan P Cárdenas, Raquel Quatrini, Renato Chávez, Gloria Levicán   +5 more
doaj   +1 more source

The thioredoxin system and not the Michaelis–Menten equation should be fitted to substrate saturation datasets from the thioredoxin insulin assay

, 2016
Introduction: The thioredoxin system, consisting of thioredoxin reductase, thioredoxin and NADPH, is present in most living organisms and reduces a large array of target protein disulfides.
Ché S. Pillay (2568265), Letrisha Padayachee (2568262)   +1 more
core   +1 more source