Results 11 to 20 of about 2,711 (217)
Localization of the thiorphan‐sensitive endopeptidase, termed enkephalinase A, on glial cells [PDF]
FEBS Letters, 1983 Degradation of tritiated Leu‐enkephalin was studied in cultures of primary astrocytes from rat brain. The incubation experiments with a cell suspension revealed Tyr as the main tritiated metabolite; however, Tyr—Gly—Gly and Tyr—Gly were detectable as well.
Hans Lentzen, J. Palenker
semanticscholar +5 more sources
Substance P and thiorphan synergically enhance angiogenesis in wound healing [PDF]
Tissue Engineering and Regenerative Medicine, 2016 Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP).
Jihyun Um +3 more
semanticscholar +5 more sources
Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan. [PDF]
Proceedings of the National Academy of Sciences, 1983 Thiorphan, N-[(R,S)-3-mercapto-2-benzylpropanoyl]glycine is a highly potent inhibitor (Ki = 3.5 nM) of "enkephalinase," a metalloendopeptidase cleaving the Gly-Phe bond (positions 3 and 4) of enkephalins in brain tissue. In accordance with this property, thiorphan displays antinociceptive activity after systemic administration.
B. P. Roques +4 more
semanticscholar +6 more sources
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice [PDF]
Brain, 2006 Excitotoxic damage appears to be a critical factor in the formation of perinatal brain lesions associated with cerebral palsy (CP). When injected into newborn mice, the glutamatergic analogue, ibotenate, produces cortical lesions and white matter cysts that mimic human perinatal brain lesions.
Fadia Medja +9 more
semanticscholar +6 more sources
A comprehensive review of the pharmacodynamics, pharmacokinetics and clinical effects of the neutral endopeptidase inhibitor racecadotril [PDF]
Frontiers in Pharmacology, 2012 Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP including enkephalins and atrial natriuretic peptide.
Marion eEberlin +2 more
doaj +5 more sources
Significance of CD10 for Mucosal Immunomodulation by β-Casomorphin-7 in Exacerbation of Ulcerative Colitis [PDF]
Current Issues in Molecular Biologyβ-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear.
Yoshihiro Miyagawa +9 more
doaj +2 more sources
Opioid Withdrawal Abruptly Disrupts Amygdala Circuit Function by Reducing Peptide Actions. [PDF]
J Neurosci, 2023 While the physical signs of opioid withdrawal are most readily observable, withdrawal insidiously drives relapse and contributes to compulsive drug use, by disrupting emotional learning circuits.
Gregoriou GC +4 more
europepmc +3 more sources
Japanese Journal of Pharmacology, 1986 The enkephalin-hydrolyzing peptidases in mouse vas deferens were studied and compared with those in guinea pig ileum which had been characterized in the previous study.
Kazuko Aoki, Midori Kajiwara, Tetsuo Oka
openalex +2 more sources
Japanese Journal of Pharmacology, 1986 The contents of [Met5]-enkephalin and its four hydrolysis products, Tyr, Tyr-Gly, Tyr-Gly-Gly, and Tyr-Gly-Gly-Phe, in the sample obtained after enkephalin was incubated with tissues in either the absence or the presence of the peptidase inhibitor were ...
Toyokazu Hiranuma, Tetsuo Oka
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Japanese Journal of Pharmacology, 1984 The role of each enkephalin-hydrolyzing peptidase in the inhibitory potency of exogenously added enkephalins in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum was studied by using the relatively specific inhibitor of each enzyme.
Kazuko Aoki, Midori Kajiwara, Tetsuo Oka
openalex +2 more sources