Results 51 to 60 of about 2,776 (198)
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. [PDF]
, 2014 This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/bph.12874Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three ...
Davenport, AP, Maguire, JJ
core +4 more sources
Journal of Diabetes Research, 2014 We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang +3 more
doaj +1 more source
Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...
Andrikopoulos, Sofianos +5 more
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Journal of Biological Chemistry, 2001 To identify the amyloid β peptide (Aβ) 1–42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and cloned neprilysin-likepeptidase (NEPLP) α, NEPLP β, and NEPLP γ cDNAs.
K. Shirotani +11 more
semanticscholar +1 more source
Mapping small molecule binding data to structural domains. [PDF]
, 2012 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Kruger, Felix A +2 more
core +3 more sources
Pharmacogenomics and Personalized Medicine, 2022 Huasheng Huang,* Xiwen Liao,* Guangzhi Zhu, Chuangye Han, Xiangkun Wang, Chengkun Yang, Xin Zhou, Tianyi Liang, Ketuan Huang, Tao Peng Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning ...
Huang H +9 more
doaj
Treatment of Acute Diarrhoea: Past and Now [PDF]
, 2015 Context: Since ancient times diarrhoea has been a highly fatal disease and even today diarrhoea, the topic of this review, is a problem affecting millions of people around the world despite the efforts of governments and professionals from the medical ...
Caramia, Giuseppe +3 more
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Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin +3 more
wiley +1 more source
, 2015 The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype.
Davenport, Anthony P +8 more
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FEBS Letters, Volume 598, Issue 13, Page 1576-1590, July 2024.This study aimed to elucidate the impact of glutathione depletion on aging and neurodegeneration in Alzheimer's pathology (amyloid and tau pathologies). We demonstrated that glutathione reduction, mediated by glutamate‐cysteine ligase catalytic subunit (GCLC) deficiency, elevated Aβ42/40 levels and facilitated tau polymerization through disulfide‐bond ...
Khairun Nisa Binti Hashim +6 more
wiley +1 more source