From ARB to ARNI in Cardiovascular Control [PDF]
, 2016 Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality.
Danser, A.H.J. (Jan) +3 more
core +1 more source
Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11 [PDF]
, 2016 Background: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides.
Jong, M. (Marion) de +6 more
core +5 more sources
Beneficial effects of combined AT1 receptor/neprilysin inhibition (ARNI) versus AT1 receptor blockade alone in the diabetic eye [PDF]
, 2016 PURPOSE. Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS,
Batenburg, W.W. (Wendy) +8 more
core +5 more sources
Bradykinin Release Avoids High Molecular Weight Kininogen Endocytosis [PDF]
, 2015 Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis.
Araujo, Mariana S. +9 more
core +7 more sources
Thiorphan-Induced Survival and Proliferation of Rat Thymocytes by Activation of Akt/Survivin Pathway and Inhibition of Caspase-3 Activity [PDF]
Journal of Pharmacology and Experimental Therapeutics, 2008 C. Amantini +4 more
semanticscholar +2 more sources
Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT(1)/AT(2) receptors to activate SERCA and to promote Ca2+ mobilization [PDF]
, 2012 Ferrao FM, Lara LS, Axelband F, Dias J, Carmona AK, Reis RI, Costa-Neto CM, Vieyra A, Lowe J. Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT(1)/AT(2) receptors to activate SERCA and to promote Ca2+ mobilization.
Axelband, Flavia +8 more
core +1 more source
Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?
Pharmaceuticals, 2015 Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq +3 more
doaj +1 more source
Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease [PDF]
, 2015 Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP) and cerebrovascular amyloid protein deposits that are defining diagnostic features of Alzheimer's disease (AD). A number of rare mutations linked to familial AD (FAD)
Baranello, Robert J. +7 more
core +1 more source
Sex differences in the aging pattern of renin–angiotensin system serum peptidases [PDF]
, 2017 BACKGROUND: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin–angiotensin system ...
A. B. Fraile-Bermúdez +7 more
core +5 more sources
Why dried blood spots are an ideal tool for CYP1A2 phenotyping [PDF]
, 2014 Background and Objective: Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies.
De Kesel, Pieter +2 more
core +2 more sources