Results 51 to 60 of about 2,711 (217)
The FASEB Journal, Volume 34, Issue 9, Page 12922-12931, September 2020., 2020 Abstract Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. However, the involvement of
Rocío Pérez‐González +5 more
wiley +1 more source
Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects [PDF]
, 2019 Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date.
Bailey, A +8 more
core +2 more sources
Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice
Physiological Reports, Volume 8, Issue 3, February 2020., 2020 Decreased intrarenal NEP, which could have a pivotal role in the pathogenesis of diabetic kidney disease. Urinary NEP could be an index of intra‐renal NEP status. The renoprotective effects of rosiglitazone could be mediated by the up‐regulation of renal NEP expression and activity in db/db diabetic mice. Abstract Alteration in renin‐angiotensin system
Laale F. Alawi +6 more
wiley +1 more source
Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway [PDF]
, 2013 Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease.
Brower, Christopher S. +2 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020 This study aimed to investigate the mechanisms of Kai‐Xin‐San (KXS, a famous Chinese herbal decoction used to treat amnesia) on the degradation of Aβ and further elucidate the mechanism of KXS on Aβ‐induced memory dysfunction. After pretreatment with KXS (1.08 g/kg/day) for two weeks, Aβ42 (2 μL, 200 μM) was injected into rat hippocampus to induce ...
Na Wang +7 more
wiley +1 more source
The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes [PDF]
, 2009 Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of ...
Carmona, Adriana Karaoglanovic +2 more
core +3 more sources
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. [PDF]
, 2014 This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/bph.12874Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three ...
Davenport, AP, Maguire, JJ
core +4 more sources
ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function [PDF]
, 2010 Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice.
Belinson, Haim +6 more
core +4 more sources
Sex differences in the aging pattern of renin–angiotensin system serum peptidases [PDF]
, 2017 BACKGROUND: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin–angiotensin system ...
A. B. Fraile-Bermúdez +7 more
core +1 more source
Journal of Diabetes Research, 2014 We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang +3 more
doaj +1 more source