Results 61 to 70 of about 2,776 (198)

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [PDF]

, 2016
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors.
Alexandrou, AJ, Brown, AR, Butt, RP, Castle, NA, Chapman, ML, Cox, PJ, Dib-Hajj, SD, Doyle, R, Estacion, M, Gutteridge, A, Hounshell, JA, Krafte, D, Lin, Z, Marron, BE, Mis, MA, Patel, MK, Payne, EC, Printzenhoff, D, Randall, A, Rivara, M, Stevens, EB, Storer, RI, Stupple, PA, Swain, NA, Turner, J, Waxman, SG, West, C, Wilbrey, A   +27 more
core   +1 more source

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Food Frontiers, Volume 5, Issue 2, Page 708-721, March 2024.
Defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber have notable improvement effects on obese mice. However, their potential anti‐obesity mechanisms share similarities and differences, which contributes to the advancement of personalized dietary development in the future.
Bing Zheng, Xiaole Zhao, Tianxiang Ao, Jianhua Xie, Yi Chen, Yueyao Gui, Xingcai Gao, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source

Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective

Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.
Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Asmaa A. Khalifa, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source

Role of endogenous endothelin-1 in the pathogenesis of gastric mucosal injury induced by local ischemia and reperfusion in rats [PDF]

, 1998
Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no.
Hassan Mahmudul
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Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]

, 2005
Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L., Ehrlich, Michelle E., Gandy, Sam, Ghiso, Jorge, Pedrini, Steve   +4 more
core   +1 more source

Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery

Journal of Pharmacy and Pharmacology, 2003
Abstract Relaxation induced by bradykinin is diminished by hypoxia in epicardial coronary arteries. The bradykinin-degrading enzyme, neutral endopeptidase (NEP, EC.3.4.24.11), is a potential target for coronary artery vasodilators. In this study, we examined the effect of thiorphan, an inhibitor of NEP, on the tone of porcine isolated ...
Irén, Krassói, János, Pataricza, Julius Gy, Papp   +2 more
openaire   +2 more sources

The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.

Japanese Journal of Pharmacology, 1984
The role of each enkephalin-hydrolyzing peptidase in the inhibitory potency of exogenously added enkephalins in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum was studied by using the relatively specific inhibitor of each enzyme.
K. Aoki, M. Kajiwara, T. Oka
semanticscholar   +1 more source

Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats [PDF]

British Journal of Pharmacology, 2003
Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin‐1 (ET‐1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan, a NEP inhibitor, in a rat cirrhosis model.
K S, Park, Y, Li, Y, Zhang, A L, Gerbes, H, Liu, M G, Swain, S S, Lee   +6 more
openaire   +2 more sources

Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity.

Journal of Pharmacobio-Dynamics, 1985
The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine.
M, Hachisu, H, Takahashi, T, Hiranuma, Y, Shibazaki, S, Murata   +4 more
openaire   +3 more sources

Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis [PDF]

, 2018
Alzheimer's disease, responsible for the vast majority of dementia cases in the elderly population, is caused by accumulation of toxic levels of amyloid β peptide (Aβ) in the brain.
Mohajeri, M., Wolfer, David
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