Results 61 to 70 of about 2,711 (217)
Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...
Andrikopoulos, Sofianos +5 more
core +1 more source
Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin +3 more
wiley +1 more source
Mapping small molecule binding data to structural domains. [PDF]
, 2012 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Kruger, Felix A +2 more
core +3 more sources
FEBS Letters, Volume 598, Issue 13, Page 1576-1590, July 2024.This study aimed to elucidate the impact of glutathione depletion on aging and neurodegeneration in Alzheimer's pathology (amyloid and tau pathologies). We demonstrated that glutathione reduction, mediated by glutamate‐cysteine ligase catalytic subunit (GCLC) deficiency, elevated Aβ42/40 levels and facilitated tau polymerization through disulfide‐bond ...
Khairun Nisa Binti Hashim +6 more
wiley +1 more source
Food Frontiers, Volume 5, Issue 2, Page 708-721, March 2024.Defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber have notable improvement effects on obese mice. However, their potential anti‐obesity mechanisms share similarities and differences, which contributes to the advancement of personalized dietary development in the future.
Bing Zheng +8 more
wiley +1 more source
Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective
Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali +8 more
wiley +1 more source
Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production
Journal of Cellular and Molecular Medicine, Volume 20, Issue 9, Page 1686-1695, September 2016., 2016 Abstract Mitochondria are physically and biochemically in contact with other organelles including the endoplasmic reticulum (ER). Such contacts are formed between mitochondria‐associated ER membranes (MAM), specialized subregions of ER, and the outer mitochondrial membrane (OMM).
Nuno Santos Leal +7 more
wiley +1 more source
Role of endogenous endothelin-1 in the pathogenesis of gastric mucosal injury induced by local ischemia and reperfusion in rats [PDF]
, 1998 Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no.
Hassan Mahmudul
core
The Danger to the Chemical Weapons Convention from Incapacitating Chemicals [PDF]
, 2003 Ye
Dando, Malcolm R.
core
Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]
, 2005 Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L. +4 more
core +1 more source