Results 61 to 70 of about 2,737 (218)
Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance
Frontiers in Aging Neuroscience, 2014 Accumulation of the amyloid-beta (Ab) peptide is a central factor in Alzheimer’s disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Ab in AD before discussing the ...
Robert eMarr, Daniel eHafez
doaj +1 more source
Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects [PDF]
, 2019 Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date.
Bailey, A +8 more
core +2 more sources
Aging Cell, Volume 19, Issue 11, November 2020., 2020 AICD‐mediated regulatory feedback cycle of IDE and APP processing. Abstract One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques.
Anna A. Lauer +13 more
wiley +1 more source
The FASEB Journal, Volume 34, Issue 9, Page 12922-12931, September 2020., 2020 Abstract Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. However, the involvement of
Rocío Pérez‐González +5 more
wiley +1 more source
Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway [PDF]
, 2013 Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease.
Brower, Christopher S. +2 more
core +2 more sources
Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice
Physiological Reports, Volume 8, Issue 3, February 2020., 2020 Decreased intrarenal NEP, which could have a pivotal role in the pathogenesis of diabetic kidney disease. Urinary NEP could be an index of intra‐renal NEP status. The renoprotective effects of rosiglitazone could be mediated by the up‐regulation of renal NEP expression and activity in db/db diabetic mice. Abstract Alteration in renin‐angiotensin system
Laale F. Alawi +6 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020 This study aimed to investigate the mechanisms of Kai‐Xin‐San (KXS, a famous Chinese herbal decoction used to treat amnesia) on the degradation of Aβ and further elucidate the mechanism of KXS on Aβ‐induced memory dysfunction. After pretreatment with KXS (1.08 g/kg/day) for two weeks, Aβ42 (2 μL, 200 μM) was injected into rat hippocampus to induce ...
Na Wang +7 more
wiley +1 more source
The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes [PDF]
, 2009 Proteolytic enzymes have a fundamental role in many biological processes and are associated with multiple pathological conditions. Therefore, targeting these enzymes may be important for a better understanding of their function and development of ...
Carmona, Adriana Karaoglanovic +2 more
core +3 more sources
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. [PDF]
, 2014 This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/bph.12874Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three ...
Davenport, AP, Maguire, JJ
core +4 more sources
Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx [PDF]
, 2014 Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced ...
Andrikopoulos, Sofianos +5 more
core +1 more source