Functionalizing Thiosemicarbazones for Covalent Conjugation [PDF]
MoleculesThiosemicarbazones (TSCs) with their modular character (thiosemicarbazides + carbonyl compound) allow broad variation of up to four substituents on the main R1R2C=N(1)–NH–C(S)–N(4)R3R4 core and are thus interesting tools for the formation of conjugates ...
Johannes Hohnsen +5 more
doaj +6 more sources
Ni(II), Pd(II) and Pt(II) complexes with ligand containing thiosemicarbazone and semicarbazone moiety: synthesis, characterization and biological investigation [PDF]
, 2008 The synthesis of nickel(II), palladium(II) and platinum(II) complexes with thiosemicarbazone and semicarbazone of p-tolualdehyde are reported. All the new compounds were characterized by elemental analysis, molar conductance measurements, magnetic ...
MONIKA TYAGI, SULEKH CHANDRA
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Rhenium mixed-ligand complexes with S,N,S-tridentate thiosemicarbazone/thiosemicarbazide ligands [PDF]
, 2013 Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H2L1) derived from N-[N′,N′-dialkylamino(thiocarbonyl)]benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have been synthesized by ligand-exchange reactions starting ...
Bergemann, Silke +5 more
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In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease [PDF]
PharmaceuticsBackground/Objectives: Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silico/in
Lidiane Meier +11 more
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Conformational and Functional Properties of the Bioactive Thiosemicarbazone and Thiocarbohydrazone Compounds [PDF]
Current Issues in Molecular BiologyThiosemicarbazones and thiocarbohydrazones are key sulfur-containing organic compounds known for their diverse biological, pharmaceutical, and industrial applications.
Nikitas Georgiou +4 more
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Thiosemicarbazones as Aedes aegypti larvicidal
European Journal of Medicinal Chemistry, 2015 A set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to
João Bosco P. da Silva +17 more
openaire +4 more sources
5-Hydroxypicolinaldehyde Thiosemicarbazone [PDF]
, 2020 National Cancer Institute
openaire +2 more sources
Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase [PDF]
Scientific ReportsDihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a promising target for drug development against various diseases, including cancer and tuberculosis.
Hina Aftab +9 more
doaj +2 more sources
Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones [PDF]
Journal of the Serbian Chemical Society, 2021 In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR ...
Čobeljić Božidar R. +6 more
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Trigonal-bipyramidal vs. octahedral coordination in indium(III) complexes with potentially S,N,S‐tridentate thiosemicarbazones [PDF]
, 2020 Three bis‐chelates of indium(III) with (partially fluorinated) S,N,S‐tridentate thiosemicarbazones (H2L) were prepared and their structures were studied in solution and in the solid state by NMR, ESI MS and single‐crystal X‐ray diffraction.
Abram, Ulrich +3 more
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