Results 171 to 180 of about 7,220 (228)

Hydroxyalkyne-Bithiophene Derivatives: Synthesis and Antileishmanial Activity. [PDF]

Chem Biol Drug Des
Machado RRB, Salvador DL, Gomes CMB, Bakoshi ABK, Ueda-Nakamura T, de Oliveira Silva S, Nakamura CV, Sarragiotto MH, Lazarin-Bidóia D.   +8 more
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Synthesis and anticancer activity of thiosemicarbazones

Bioorganic and Medicinal Chemistry Letters, 2006
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901.
Wei-Xiao Hu, Chun-Nian Xia, Xi Wen
exaly   +3 more sources

Antifungal activity of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes

Journal of Inorganic Biochemistry, 2021
Fungi are ubiquitous in nature, and typically cause little or no environmental or pathogenic damage to their plant, animal, and human hosts. However, a small but growing number of pathogenic fungi are spreading world-wide at an alarming rate threatening global ecosystem health and proliferation.
Kritika, Bajaj, Robert M, Buchanan, Craig A, Grapperhaus   +2 more
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Structure of salicylaldehyde thiosemicarbazone

Acta Crystallographica Section C Crystal Structure Communications, 1988
C8H9N3OS, monoclinic, C2/c, a = 14.206 (3), b = 14.244 (4), c = 10.457 (4) A, beta = 116.18(2) degrees, V = 1898.9 (8) A3, Z = 8, Dm = 1.387, D chi = 1.366 g cm-3, lambda(Mo K alpha) = 0.71069 A, mu = 2.90 cm-1, F(000) = 816.0, T = 298 K, final R = 0.0429 for 1322 observed reflections. The S and hydrazinic N atoms lie trans.
D, Chattopadhyay, S K, Mazumdar, T, Banerjee, S, Ghosh, T C, Mak   +4 more
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Biodistribution of 59Fe-thiosemicarbazones

International Journal of Nuclear Medicine and Biology, 1982
The 59Fe-iron(II) chelates of 2-formylpyridine thiosemicarbazone (I), 5-dimethylamino-2-formylpyridine thiosemicarbazone (II), and 5-hydroxy-2-formylpyridine thiosemicarbazone (III) were prepared and their biodistribution determined in normal rats. Early accumulation of these complexes occurred in the liver, muscle and pelt with lesser amounts in the ...
R N, Hanson, M A, Davis
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Semicarbazones and thiosemicarbazones. VII. Structure of 2-hydroxyacetophenone thiosemicarbazone

Acta Crystallographica Section C Crystal Structure Communications, 1988
Cristallisation dans P 21n avec affinement jusqu'a 0,042. L'atome S est situe en trans par rapport a l'atome N du groupe hydrazine.
M. Soriano-García, J. Valdés-Martínez, R. A. Toscano   +2 more
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Semicarbazones and thiosemicarbazones, XIII: Study of the hydrolysis of coordinated thiosemicarbazones

Monatshefte f�r Chemie Chemical Monthly, 1991
The hydrolysis of coordinated thiosemicarbazones was studied. It was found that the nickel(II) ion promotes the reaction. Steric and electronic influences were found. The hydrolysis ofATSC in the trigonal bipyramid compounds [M(ATSC)2Cl]Cl [M=Fe(II), Co(II), Ni(II)], is higher with the Ni(II) complex, the compound with the shorterM-N distance.
Armando Cabrera, Alfonso Diaz-Tejeda, Carmen Marquez, Jes�s Vald�s-Mart�nez   +3 more
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Formation of ‘Heinz Bodies’ by a Thiosemicarbazone

Nature, 1952
THE marked suppressive action which p-acetyl-amino-benzal-thiosemicarbazone exerts in experimental tuberculosis as first shown by Domagk1, and its effect in certain forms of human tuberculosis as reported by Mertens and Bunge2, make the study of toxic side-effects of this drug an urgent necessity.
C O, SIEBENMAN, A, ZUBRYS
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Thiosemicarbazones as Aedes aegypti larvicidal

European Journal of Medicinal Chemistry, 2015
A set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to
João Bosco P. da Silva, Daniela Maria do A.F. Navarro, Aluizio G. da Silva, Geanne K.N. Santos, Kamilla A. Dutra, Diogo Rodrigo Moreira, Mozart N. Ramos, José Wanderlan P. Espíndola, Ana Daura T. de Oliveira, Dalci José Brondani, Ana Cristina L. Leite, Marcelo Zaldini Hernandes, Valéria R.A. Pereira, Lucas F. da Rocha, Maria Carolina A.B. de Castro, Beatriz C. de Oliveira, Que Lan, Kenneth M. Merz   +17 more
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Thiosemicarbazones as inhibitors of tyrosinase enzyme

Bioorganic & Medicinal Chemistry Letters, 2017
In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A, Soares, Mariana A, Almeida, Carla, Marins-Goulart, Otávio A, Chaves, Aurea, Echevarria, Márcia C C, de Oliveira   +5 more
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