Results 171 to 180 of about 14,086 (252)

Synthesis and anticancer activity of thiosemicarbazones

Bioorganic and Medicinal Chemistry Letters, 2006
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901.
Wei-Xiao Hu, Chun-Nian Xia, Xi Wen
exaly   +3 more sources

Applications of radiocomplexes with thiosemicarbazones and bis(thiosemicarbazones) in diagnostic and therapeutic nuclear medicine

Coordination Chemistry Reviews, 2022
Gabrieli L Parrilha, Raquel G Dos Santos, Heloisa Beraldo   +2 more
exaly   +2 more sources

Thiosemicarbazones as inhibitors of tyrosinase enzyme

Bioorganic & Medicinal Chemistry Letters, 2017
In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A, Soares, Mariana A, Almeida, Carla, Marins-Goulart, Otávio A, Chaves, Aurea, Echevarria, Márcia C C, de Oliveira   +5 more
openaire   +3 more sources

Synthesis, characterization, and anticancer activity of chitosan functionalized isatin based thiosemicarbazones, and their copper(II) complexes.

Carbohydrate Research, 2023
The one-pot synthetic method of condensation of isatin and 5-chloroisatin on to amino group at C2 position of the pyranose ring chitosan in chitosan thiosemicarbazide was employed to get these chitosan thiosemicarbazones (TSCs). The partial incorporation
Hari Sharan Adhikari, Aditya Garai, P. Yadav   +2 more
semanticscholar   +1 more source

Synthesis, characterization, and biological properties of mono-, di- and poly-nuclear bismuth(III) halide complexes containing thiophene-2-carbaldehyde thiosemicarbazones.

Journal of Inorganic Biochemistry, 2022
In order to investigate the coordination chemistry and pharmacological applications of bismuth compounds, a series of new bismuth(III) halide thiosemicarbazone complexes were synthesized.
Kadriye Turk, A. Grześkiewicz, C. Banti, S. Hadjikakou, M. Kubicki, I. Ozturk   +5 more
semanticscholar   +1 more source

Anticancer potency of copper(II) complexes of thiosemicarbazones.

Journal of Inorganic Biochemistry, 2020
Being a structural and catalytic cofactor in a number of biological pathways, copper accumulates in tumors owing to selective permeability of the cancer cell membranes. Copper(II) ion forms the active centers in a large number of metalloproteins.
N. Singh, A. Kumbhar, Y. R. Pokharel, P. Yadav   +3 more
semanticscholar   +1 more source

Thiosemicarbazones as a Potent Anticancer Agents and Their Modes of Action.

Mini-Reviews in Medical Chemistry, 2020
Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been focus of chemists and biologists due to their wide range of pharmacological effects. One of
B. Shakya, P. Yadav
semanticscholar   +1 more source

Nickel(II) complexes of N(4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structures, spectral aspects and Hirshfeld surface analysis

, 2021
Seven Ni(II) complexes {[NiL12]•2H2O (1), [Ni2L22SO4]•1½H2O (2), [Ni(HL2)2](NO3)2•H2O•EtOH (3), [NiL2(HL2)]OAc•3H2O (4), [Ni(HL2)2](ClO4)2•2H2O (5), [NiL3OAc]•2½H2O (6), [NiL3NO3]•3H2O (7)} of three thiosemicarbazone ligands, viz•pyridine-2-carbaldehyde ...
P. F. Rapheal, E. Manoj, M. Kurup, H. Fun   +3 more
semanticscholar   +1 more source

Synthesis and Structural Characterization of Fluorinated Thiosemicarbazones [PDF]

Molecules, 2013
Six new fluorinated thiosemicarbazones R‑C(R′)=N-NH-C(S)NH2 (R = 2,4-C6H3F2, R′ = H (1); R = 2,5-C6H3F2, R′ = H (2); R = 2,6-C6H3F2, R′ = H (3); R = 3,4-C6H3F2, R′ = H (4); R = 3,5-C6H3F2, R′ = H (5) and R = 4-C6H4F, R′ = C6H5, (6)) have been prepared ...
Marcos Flores-Alamo, Jorge Tiburcio, Hugo Torrens   +2 more
exaly   +2 more sources

Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes.

Bioorganic chemistry (Print), 2020
With the fading of 'one drug-one target' approach, Multi-Target-Directed Ligands (MTDL) has become a central idea in modern Medicinal Chemistry.
Sadaf Hashmi, Samra Khan, Zahid Shafiq, Parham Taslimi, M. Ishaq, Nastaran Sadeghian, Halide S Karaman, N. Akhtar, Muhamamd Islam, A. Asari, H. Mohamad, I. Gulcin   +11 more
semanticscholar   +1 more source