Results 191 to 200 of about 14,086 (252)

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes.

Journal of Inorganic Biochemistry, 2019
Triapine, the most prominent anticancer drug candidate from the substance class of thiosemicarbazones, was investigated in >30 clinical phase I and II studies.
Sebastian Kallus, Lukas Uhlik, S. van Schoonhoven, K. Pelivan, W. Berger, É. A. Enyedy, T. Hofmann, P. Heffeter, C. Kowol, B. Keppler   +9 more
semanticscholar   +1 more source

Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis.

Bioorganic chemistry (Print), 2019
A set of 21 halogenated thiosemicarbazones (TSCs) have been synthesized and its inhibitory properties toward activity diphenolase of mushroom tyrosinase and their ability to inhibition of melanogenesis in B16F10 murine, melanoma cell line have been ...
K. Hałdys, W. Goldeman, M. Jewgiński, E. Wolińska, Natalia Anger-Góra, J. Rossowska, R. Latajka   +6 more
semanticscholar   +1 more source

Dioxomolybdenum(VI) complexes with 3-methoxy salicylidene-N-alkyl substituted thiosemicarbazones. Synthesis, characterization, enzyme inhibition and antioxidant activity

Journal of Molecular Structure, 2019
3-methoxysalicylidene N-alkyl-thiosemicarbazones (L) (where alkyl is propyl, butyl, pentyl or hexyl) were synthesized. The reaction of the ONS donor ligands with [MoO2(acac)2] in methanol yielded the mixed ligand complexes bearing a solvent molecule as ...
Songül Eğlence-Bakır, O. Sacan, M. Şahin, R. Yanardag, B. Ülküseven   +4 more
semanticscholar   +1 more source

Formation of ‘Heinz Bodies’ by a Thiosemicarbazone

Nature, 1952
THE marked suppressive action which p-acetyl-amino-benzal-thiosemicarbazone exerts in experimental tuberculosis as first shown by Domagk1, and its effect in certain forms of human tuberculosis as reported by Mertens and Bunge2, make the study of toxic side-effects of this drug an urgent necessity.
C O, SIEBENMAN, A, ZUBRYS
openaire   +2 more sources

Exploring antidiabetic potential of adamantyl-thiosemicarbazones via aldose reductase (ALR2) inhibition.

Bioorganic chemistry (Print), 2019
The role of aldose reductase (ALR2) in diabetes mellitus is well-established. Our interest in finding ALR2 inhibitors led us to explore the inhibitory potential of new thiosemicarbazones.
Muhammad Tariq Shehzad, A. Hameed, Mariya al‐Rashida, Aqeel Imran, Maliha Uroos, A. Asari, H. Mohamad, Muhammad Islam, Shafia Iftikhar, Zahid Shafiq, J. Iqbal   +10 more
semanticscholar   +1 more source

Thiosemicarbazones-based Co(II), Ni(II), Cu(II) and Zn(II) complexes: synthesis, structural elucidation, biological activities and molecular docking

Chemické zvesti, 2023
M. Rani, J. Devi, B. Kumar
semanticscholar   +1 more source

Thiosemicarbazones as Aedes aegypti larvicidal

European Journal of Medicinal Chemistry, 2015
A set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. aegypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to
João Bosco P. da Silva, Daniela Maria do A.F. Navarro, Aluizio G. da Silva, Geanne K.N. Santos, Kamilla A. Dutra, Diogo Rodrigo Moreira, Mozart N. Ramos, José Wanderlan P. Espíndola, Ana Daura T. de Oliveira, Dalci José Brondani, Ana Cristina L. Leite, Marcelo Zaldini Hernandes, Valéria R.A. Pereira, Lucas F. da Rocha, Maria Carolina A.B. de Castro, Beatriz C. de Oliveira, Que Lan, Kenneth M. Merz   +17 more
openaire   +2 more sources

Antimicrobial Properties of Aliphatic Thiosemicarbazones

Journal of Pharmaceutical Sciences, 1964
A series of thiosemicarbazones of saturated and α,β-unsaturated aliphatic aldehydes was prepared and tested in vitro for activity against various bacteria, yeasts, and molds. Antimicrobial potency was found to depend on chain length and was greatly enhanced by the presence of an unsaturated linkage.
M, MANOWITZ, G, WALTER
openaire   +2 more sources

A trial of thiosemicarbazones in the treatment of tuberculosis

Tubercle, 1951
Summary o (1) A brief review of the present position of Thiosemicarbazone therapy in Pulmonary Tuberculosis has been made. (2) Results of treatment of groups of cases with p-Acetylaminobenzaldehyde thiosemicarbazone and p-Ethylsulphonylbenzaldehyde thiosemicarbazone have been made.
openaire   +2 more sources

Bismuth(III) halide complexes of aromatic thiosemicarbazones: Synthesis, structural characterization and biological evaluation

, 2021
I. Ozturk, C. Banti, S. Hadjikakou, Nikos Panagiotou, A. Tasiopoulos   +4 more
semanticscholar   +1 more source