Results 21 to 30 of about 14,165 (252)

α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach [PDF]

, 2009
α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents.
Matesanz, Ana I., Souza, Pilar
core   +2 more sources

Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp [PDF]

, 2016
The limited arsenal of synthetic antifungal agents and the emergence of resistant Candida strains have prompted the researchers towards the investigation of naturally occurring compounds or their semisynthetic derivatives in order to propose new ...
ANGIOLELLA, Letizia, CARRADORI, Simone, CHIMENTI, Paola, Fazzari, Marina, GRANESE, ARIANNA   +4 more
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Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

Frontiers in Pharmacology, 2022
Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron ...
Maria Krchniakova, Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Petr Chlapek, Jakub Neradil, Jakub Neradil, Jan Skoda, Jan Skoda, Renata Veselska, Renata Veselska   +10 more
doaj   +1 more source

Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde [PDF]

, 2003
The X-ray crystal structures are reported of four novel and potentially O,N,S-tridentate donor ligands that demonstrate antitumour activity.
Bernhardt, P. V., Caldwell, L., Lovejoy, D., Richardson, D. R.   +3 more
core   +1 more source

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity

Molecules, 2005
Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described.
Cavit Kazaz, Alaaddin Çukurovali, Misir Ahmedzade, Murat Koca   +3 more
doaj   +1 more source

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Biomolecules, 2020
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H2LR]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HLR)Cl]Cl (1–4) were synthesised with the aim to study (i) their ...
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec, Vladimir B. Arion   +13 more
doaj   +1 more source

Synthesis and evaluation of fluorimetric and colorimetric chemosensors for anions based on (oligo)thienyl-thiosemicarbazones [PDF]

, 2012
A family of heterocyclic thiosemicarbazone dyes (3a-d) containing thienyl groups has been synthesized, characterized and their chromo-fluorogenic response in acetonitrile in the presence of selected anions studied.
Agostini, Aldrey, Amendola, Amendola, Amendola, Amendola, Amendola, Amendola, Atta, Batista, Batista, Batista, Batista, Batista, Batista, Beer, Beer, Blondeau, Boiocchi, Boiocchi, Bondy, Bonizzoni, Callan, Caltagirone, Camiolo, Coll, Costa, De Silva, De Silva, De Silva, Devaraj, Dos Santos, Dydio, Esteban-Gómez, Esteban-Gómez, Evans, Fabrizzi, Fitzmaurice, Formica, Félix Sancenón, Gale, Gunnlaugsson, He, Inouye, Jiménez, Jose, José Vicente Ros-Lis, Juan Soto, Jun, Kim, Krishnamurthi, Li, Li, Lin, Lin, Lloris, Luis E. Santos-Figueroa, Löhr, M. Manuela M. Raposo, Makuc, Mapathy, Martínez-Mañéz, Martínez-Máñez, Martínez-Máñez, Martínez-Máñez, Martínez-Máñez, María E. Moragues, Moragues, Nie, Odago, Piątek, Prodi, Pérez-Casas, R. Cristina M. Ferreira, Ramón Martínez-Máñez, Raposo, Raposo, Ros-Lis, Rosa M.F. Batista, Rurack, Schmidtchen, Suksai, Susana P.G. Costa, Tian, Valeur, Withnall, Xu, Xu, Yoon, Zhang   +89 more
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THE STRUCTURE OF 5-AMINO-4-METHYL-1-ISOQUINOLINECARBALDEHYDE THIOSEMICARBAZONE HYDROCHLORIDE, C12H14N5S+.CL- [PDF]

, 1984
Mr=295.80 , P21/n , a=8.284(1), b= 13.906 (1), c= 12.040 (2) A, fl= 92.95 (1) °, V= 1385.0 (5) ,/k 3, Z = 4, D m = 1.42, D x = 1.418 Mg m -3, 2(Cu K~t) = 1.54178 A,, g = 3.8134 mm -~, F(000) = 616, R =0.061 for 628 unique significant reflections ...
KURODA, R, NEIDLE, S, WILMAN, D
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Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

Ciência e Agrotecnologia, 2014
Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A.
Rojane de Oliveira Paiva, Lucimar Ferreira Kneipp, Carla Marins Goular, Mariana Almeida Albuquerque, Aurea Echevarria   +4 more
doaj   +1 more source

Synthesis, characterization, antibacterial activity of thiosemicarbazones derivatives and their computational approaches: Quantum calculation, molecular docking, molecular dynamic, ADMET, QSAR

Heliyon, 2023
The thiosemicarbazones and their derivatives have been recognized as antimicrobial agents against human pathogenic bacteria and fungi. Regarding these prospective, this study was designed to address the new antimicrobial agents from thiosemicarbazones ...
Mahbub Alam, Mohammed Nurul Abser, Ajoy Kumer, Md Mosharef Hossain Bhuiyan, Parul Akter, Md Emdad Hossain, Unesco Chakma   +6 more
doaj   +1 more source