Zoonotic Infection with Oz Virus, a Novel Thogotovirus [PDF]
Emerging Infectious Diseases, 2022 Oz virus is a novel thogotovirus isolated from ticks that causes lethal infection in mice. We conducted serosurveillance of Oz virus infection among humans and wild mammals in Japan using virus-neutralization tests and ELISAs.
Ngo T.B. Tran +14 more
doaj +6 more sources
Eight Years of Research Advances in Bourbon Virus, a Tick-borne Thogotovirus of the Orthomyxovirus Family [PDF]
Zoonoses, 2022 Bourbon virus (BRBV) was first isolated from a blood sample collected from a male patient living in Bourbon County, Kansas, during the spring of 2014. The patient later died because of complications associated with multiorgan failure.
Siyuan Hao +5 more
doaj +5 more sources
Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein. [PDF]
PLoS Pathogens, 2020 Infections with emerging and re-emerging arboviruses are of increasing concern for global health. Tick-transmitted RNA viruses of the genus Thogotovirus in the Orthomyxoviridae family have considerable zoonotic potential, as indicated by the recent ...
Jonas Fuchs +3 more
doaj +7 more sources
Characterization of Viral Communities of Biting Midges and Identification of Novel Thogotovirus Species and Rhabdovirus Genus [PDF]
Viruses, 2016 More than two thirds of emerging viruses are of zoonotic origin, and among them RNA viruses represent the majority. Ceratopogonidae (genus Culicoides) are well-known vectors of several viruses responsible for epizooties (bluetongue, epizootic ...
Sarah Temmam +9 more
doaj +9 more sources
Novel Thogotovirus Associated with Febrile Illness and Death, United States, 2014 [PDF]
Emerging Infectious Diseases, 2015 A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness.
Olga I. Kosoy +6 more
doaj +4 more sources
Comparative Study of Ten Thogotovirus Isolates and Their Distinct In Vivo Characteristics. [PDF]
J Virol, 2022 Since their discovery over 60 years ago, 15 genetically distinct members of the thogotovirus genus have been isolated. These arboviruses belong to the Orthomyxovirus family and share many features with influenza viruses.
Fuchs J +5 more
europepmc +6 more sources
Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus). [PDF]
J Med Entomol, 2021 Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Godsey MS +6 more
europepmc +6 more sources
Comprehensive Review of Emergence and Virology of Tickborne Bourbon Virus in the United States [PDF]
Emerging Infectious Diseases, 2023 The emergence of SARS-CoV-2 and the worldwide COVID-19 pandemic triggered considerable attention to the emergence and evolution of novel human pathogens. Bourbon virus (BRBV) was first discovered in 2014 in Bourbon County, Kansas, USA. Since its initial
Molly K. Roe +6 more
doaj +2 more sources
Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Thogotoviruses belong to Orthomyxoviridae family and infect a variety of mammalian hosts, including humans. The emergence of these viruses poses great threats to public health and the economy.
Ruchao Peng +5 more
openalex +4 more sources
Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins [PDF]
Virologica Sinica, 2019 Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However, the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins (GPs), such as vesicular stomatitis virus G protein (VSV G), with baculovirus ...
Liangbo Hu +5 more
openalex +4 more sources