Results 121 to 130 of about 2,239,305 (281)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Meglumine-Promoted Eco-Compatible Pseudo-Three-Component Reaction for the Synthesis of 1,1-Dihomoarylmethane Scaffolds and Their Green Credentials. [PDF]

ACS Omega, 2022
Patel MS, Parekh JN, Chudasama DD, Patel HC, Dalwadi P, Kunjadiya A, Bhatt V, Ram KR.   +7 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones. [PDF]

Molecules, 2022
Wang Z, Yang T, Liu D, Chen R, Wang N, Liu H, Li J, Wang K, Liu H.   +8 more
europepmc   +1 more source

On analysis of chemical reactions coupled gas flows in SOFCs [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Sunden, B, Yang, G, Yuan, J   +3 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines. [PDF]

RSC Adv, 2022
Zhou Z, Luo D, Li G, Yang Z, Cui L, Yang W.   +5 more
europepmc   +1 more source

Factors Affecting the Impact of CAP Scenarios on Farm Structure: An Analysis Based on Stated Intentions [PDF]

Several authors have emphasised the effect of agricultural policy (such as SFP) as a driver of structural change. This paper aims to identify the determinants of the change in the use of productive factors under different policy scenarios.
Bartolini, Fabio, Viaggi, Davide
core   +1 more source

Three-body Coulomb breakup of 11Li in the complex scaling method

, 2003
Coulomb breakup strengths of 11Li into a three-body 9Li+n+n system are studied in the complex scaling method. We decompose the transition strengths into the contributions from three-body resonances, two-body ``10Li+n'' and three-body ``9Li+n+n ...
Aguilar, Aoyama, Audi, Balslev, Berggren, Bertulani, Furutani, Garrido, Hansen, Ieki, Ikeda, Katō, Katō, Kiyomi Ikeda, Kiyoshi Katō, Kukulin, Mukai, Myo, Myo, Myo, Nakamura, Sackett, Saito, Shigeyoshi Aoyama, Shimoura, Takayuki Myo, Tang, Tanihata, Tanihata, Tosaka, Tostevin, Zhukov, Zinser   +32 more
core   +1 more source

A General Three-Component Alkyl Petasis Boron-Mannich Reaction

Journal of the American Chemical Society
Aryl amines are one of the most common moieties in biologically active molecules, and approximately 37% of drug candidates contain aromatic amines. Recent advancements in medicinal chemistry, coined as “escaping from flatland”, have led to a greater focus on accessing highly functionalized C(sp3)-rich amines to improve the physiochemical and ...
Chao Hu, Jet Tsien, Si-Jie Chen, May Kong, Rohan R. Merchant, Yuzuru Kanda, Tian Qin   +6 more
openaire   +2 more sources