Results 101 to 110 of about 3,861,733 (345)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Hopf Bifurcation in a Three-Component Reaction-Diffusion System with a Chemoattraction

Abstract and Applied Analysis, 2013
We consider a three-component reaction-diffusion system with a chemoattraction. The purpose of this work is to analyze the chemotactic effects due to the gradient of the chemotactic sensitivity and the shape of the interface.
YoonMee Ham, Sang-Gu Lee, Quoc Phong Vu
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

C₃-Alkylation of Imidazo[1,2-a]pyridines via Three-Component Aza-Friedel–Crafts Reaction Catalyzed by Y(OTf)₃

Molecules
As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc.
Kai Yang, Cai-Bo Chen, Zhao-Wen Liu, Zhen-Lin Li, Yu Zeng, Zhao-Yang Wang   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The effect of 12C + 12C rate uncertainties on the evolution and nucleosynthesis of massive stars

, 2012
[Shortened] The 12C + 12C fusion reaction has been the subject of considerable experimental efforts to constrain uncertainties at temperatures relevant for stellar nucleosynthesis.
A. Hungerford, Aguilera, Aikawa, Angulo, Arcoragi, Arnett, Arnett, Arnett, Arnett, Barrón-Palos, Bennett, Betts, Busso, C. Fryer, Caughlan, Chieffi, Clayton, Cooper, Couch, Dayras, de Jager, Descouvemont, Diaz-Torres, Diaz-Torres, Dillmann, Eggenberger, El Eid, El Eid, F. Herwig, F. X. Timmes, Ferguson, Fryer, Fuller, Fynbo, G. Rockefeller, Gasques, Grevesse, Gropp, Heger, Hirschi, Hirschi, Hix, Iapichino, Iliadis, Imanishi, Imbriani, Imbriani, Itoh, Itoh, Jaeger, Jiang, Jiang, K. Nomoto, Kondo, Kunz, Käppeler, Lamb, Limongi, M. E. Bennett, M. Pignatari, M. Wiescher, Maeder, Mauron, Meynet, Michaud, Montes, Mukhamedzhanov, Nugis, Oda, Perez-Torres, Peters, Pignatari, Prantzos, R. Hirschi, Raiteri, Raiteri, Rauscher, Rauscher, Rauscher, Rogers, S. Diehl, Spillane, Strieder, Strieder, Terrasi, The, The, Tinsley, Travaglio, Truran, Truran, Tur, Vink, Woosley, Woosley, Woosley, Xu, Yakovlev, Young   +98 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source