Results 101 to 110 of about 16,937,278 (294)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H‑Azirines”

, 2018
Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H ...
Luc Van Meervelt (1501579), Erik V. Van der Eycken (1574857), Nagarajan Ramkumar (1856593)   +2 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Palladium-Catalyzed Enantiospecific Three-Component Reaction for the Synthesis of 1,2,4-Trisubstituted Homoallylic Alcohols

Organics
1,2,4-Trisubstituted chiral homoallylic alcohols are valuable intermediates in natural product synthesis and complex molecular architectures; however, their catalytic asymmetric synthesis remains challenging due to the need for precise control of ...
Ayumu Natsubori, Momoka Ikeda, Yushin Hosokawa, Mizuki Akagawa, Yoshikazu Horino   +4 more
doaj   +1 more source

Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides. [PDF]

ACS Omega, 2022
Koumpoura CL, Nguyen M, Bijani C, Vendier L, Salina EG, Buroni S, Degiacomi G, Cojean S, Loiseau PM, Benoit-Vical F, García-Sosa AT, Anne Robert, Baltas M.   +12 more
europepmc   +1 more source

Three-component Mannich-type reaction catalyzed by iodine

, 2006
1759-1761Iodine catalyzes Mannich-type reaction of aldehydes, benzyl carbamate and silyl ketene acetal in a three component condensation to afford the corresponding Cbz protected b-amino esters in high ...
Dolly Kataki, Kataki, Dolly, Phukan, Prodeep, Prodeep Phukan   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Palladium-catalyzed asymmetric three-component reaction between glyoxylic acid, sulfonamides and arylboronic acids for the synthesis of α-arylglycine derivatives. [PDF]

Front Chem, 2023
Jakob B, Diehl AM, Horst K, Kelm H, Manolikakes G.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source