pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Dissociation of 8B in the Coulomb Field and the Validity of the CD Method
, 2007 The GSI1, GSI2 (as well as the RIKEN2 and the corrected GSI2) measurements of the Coulomb Dissociation (CD) of 8B are in good agreement with the most recent Direct Capture (DC) 7Be(p,g)8B reaction measurement performed at Weizmann and in agreement with ...
Gai, Moshe
core +1 more source
Palladium-catalyzed asymmetric three-component reaction between glyoxylic acid, sulfonamides and arylboronic acids for the synthesis of α-arylglycine derivatives. [PDF]
Front Chem, 2023 Jakob B +4 more
europepmc +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction. [PDF]
Beilstein J Org Chem, 2023 Xiao Z, Xu F, Sun J, Yan CG.
europepmc +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
, 2007 International audienceA new strategy from simple cyclic β-ketoesters or amides involving a selective three-component reaction and a ring closing metathesis or a palladium catalyzed carbocyclization in a sequential fashion to access spiro-heterocycles is ...
Habib-Zahmani, Hadjira +2 more
core +4 more sources
Three-Component Reaction of 3-Formyl-6-Methylchromone, Primary Amines, and Secondary Phosphine Oxides: A Synthetic and Mechanistic Study. [PDF]
ACS Omega, 2023 Popovics-Tóth N +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Meglumine-Promoted Eco-Compatible Pseudo-Three-Component Reaction for the Synthesis of 1,1-Dihomoarylmethane Scaffolds and Their Green Credentials. [PDF]
ACS Omega, 2022 Patel MS +7 more
europepmc +1 more source