Results 51 to 60 of about 15,428,250 (243)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Predicting Three-Component Reaction Outcomes from 40k Miniaturized Reactant Combinations [PDF]

Efficient drug discovery relies on accessing diverse small molecules expediently and reliably. Improvements to reliability through machine learning predictions are hampered by poor availability of high-quality reaction data.
Yu, Takahashi, Iain, Stepek, Julian, Götz, Louis, Bertschi, Bertran, Rubi, Euan, Richards, Yi-Lin, Huang, Jeffrey, Bode   +7 more
core   +2 more sources

Crystal structure of 3-benzyl-2-[(E)-2-(furan-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one and 3-benzyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-2,3-dihydroquinazolin-4(1H)-one from synchrotron X-ray diffraction

Acta Crystallographica Section E: Crystallographic Communications, 2018
The chiral title compounds, C21H18N2O2, (I), and C21H18N2OS, (II) – products of the three-component reaction between benzylamine, isatoic anhydride and furyl- or thienyl-acrolein – are isostructural and form isomorphous racemic crystals.
Flavien A. A. Toze, Vladimir P. Zaytsev, Lala V. Chervyakova, Elisaveta A. Kvyatkovskaya, Pavel V. Dorovatovskii, Victor N. Khrustalev   +5 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Efficient sodium selenate-catalyzed synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2009
Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields.
Rahim Hekmatshoar, Maryam Heidari, Majid M. Heravi, Bita Baghernejad   +3 more
doaj  

Microwave-Assisted Three Component Cyclocondensation Reaction: A Facile Synthesis of Highly Functionalized Cyclohexene Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2007
Microwave-assisted three component cyclocondensation reactions of aldehydes, amides and dienophiles in the presence of acetic anhydride and para-toluenesulfonic acid as a catalyst to afford the highly substituted cyclohexene derivatives, in relatively ...
Ahmad Shaabani, Peiman Mirzaei
doaj  

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

A Facile Synthesis of Polysubstituted Pyrroles by One-Pot Three-Component Reaction

E-Journal of Chemistry, 2012
A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described.
Hossein Anaraki-Ardakani, Maziar Noei, Mina Karbalaei-Harofteh, Shahab Zomorodbakhsh   +3 more
doaj   +1 more source

N-methylimidazole mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions [PDF]

Journal of the Serbian Chemical Society, 2015
Microwave-assisted three-component reaction has been established for the synthesis of aryl alkyl ethers. The reaction was carried out under solvent free conditions in the presence of N-methylimidazole and dialkylacetylenedicarboxylate to furnish
Djahaniani Hoorieh, Aghadadashi-Abhari Laila, Mohtat Bita   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source