Results 61 to 70 of about 15,428,250 (243)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Planar radial spots in a three-component FitzHugh-Nagumo system
, 2011 Localized planar patterns arise in many reaction-diffusion models. Most of the paradigm equations that have been studied so far are two-component models.
van Heijster, Peter +3 more
core +1 more source
Molecules, 2012 A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3 ...
Yucheng Wang +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Chiral Brønsted acid-catalyzed enantioselective three-component Povarov reaction.
, 2009 International audienceThe three-component Povarov reaction of aldehydes (2), anilines (3), and benzyl N-vinylcarbamate 4 in the presence of 0.1 equiv of chiral phosphoric acid 5 afforded cis-2,4-disubstituted tetrahydroquinolines (1) in good yields and ...
Liu, Hua +4 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Orbital: The Electronic Journal of Chemistry, 2019 A simple, efficient, and green procedure for the solvent-free synthesis of 1-amido/thioamidoalkyl-2-naphthols by one-pot stirring of starting reactants at 100 °C has been introduced.
Hassan Darbandi, Hamzeh Kiyani
doaj +3 more sources
Silver-catalyzed synthesis of β-fluorovinylphosphonates by phosphonofluorination of aromatic alkynes
Beilstein Journal of Organic Chemistry, 2020 A silver-catalyzed three-component reaction involving alkynes, Selectfluor®, and diethyl phosphite was employed for the one-pot formation of C(sp2)–F and C(sp2)–P bonds to provide an efficient access to β-fluorovinylphosphonates in a highly regio- and ...
Yajing Zhang +3 more
doaj +1 more source
Bismuth Triflate-Catalyzed Three-Component Mannich-Type Reaction [PDF]
The Journal of Organic Chemistry, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Thierry, Ollevier, Etienne, Nadeau
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source