Results 41 to 50 of about 288,586 (288)

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation.

Blood, 2016
Thrombin-induced cellular response in platelets not only requires protease-activated receptors (PARs), but also involves another thrombin receptor, the glycoprotein Ib-IX complex (GPIb-IX).
Brian Estevez, Kyungho Kim, M. K. Delaney, Aleksandra Stojanovic-Terpo, Bo Shen, C. Ruan, Jaehyung Cho, Z. M. Ruggeri, Xiaoping Du   +8 more
semanticscholar   +1 more source

Safety of topical thrombins: the ongoing debate

Patient Safety in Surgery, 2009
Until recently, only bovine-derived thrombin was available for use as a stand-alone topical hemostat or as a component of other hemostatic devices. Concerns over a number of case reports of immune-mediated coagulopathies associated with the use of bovine-
Lomax Christopher
doaj   +1 more source

Modulation of the Thrombin Pathway Restores LTP in a Pilocarpine Mice Model of Status Epilepticus

Frontiers in Cellular Neuroscience, 2022
BackgroundStatus epilepticus (SE) leads to memory impairment following a seizure, attributed to long-term potentiation (LTP) reduction. Thrombin, a coagulation factor that activates protease-activated receptor 1 (PAR1) is involved in cognitive impairment
Efrat Shavit-Stein, Efrat Shavit-Stein, Efrat Shavit-Stein, Shani Berkowitz, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Amir Dori, Amir Dori, Nicola Maggio, Nicola Maggio, Nicola Maggio, Nicola Maggio   +14 more
doaj   +1 more source

Stimulation of bone growth with thrombin peptide derivatives [PDF]

, 2005
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to ...
Carney, Darrell H., Crowther, Roger S., Redin, William R., Simmons, David J., Yang, Jinping   +4 more
core   +2 more sources

Thrombin-receptor antagonist vorapaxar in acute coronary syndromes.

New England Journal of Medicine, 2012
BACKGROUND Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients
P. Tricoci, Zhen Huang, C. Held, D. Moliterno, P. Armstrong, F. Van de Werf, H. White, P. Aylward, L. Wallentin, E. Chen, Y. Lokhnygina, J. Pei, S. Leonardi, Tyrus L. Rorick, A. Kilian, L. Jennings, G. Ambrosio, C. Bode, Á. Cequier, J. Cornel, R. Diaz, A. Erkan, K. Huber, M. Hudson, Lixin Jiang, J. Jukema, B. Lewis, A. Lincoff, G. Montalescot, J. Nicolau, H. Ogawa, M. Pfisterer, J. Prieto, W. Rużyłło, P. Sinnaeve, R. Storey, M. Valgimigli, D. Whellan, P. Widimsky, J. Strony, R. Harrington, K. Mahaffey   +41 more
semanticscholar   +1 more source

Inhibition of bovine platelets aggregation in response to Hyalomma anatolicum salivary gland proteins/peptides [PDF]

Veterinary World, 2016
Aim: Ticks are obligate ectoparasites that have an impact on wide range of vertebrates and also act as a potential vector for the transmission of tropical theileriosis, babesiosis, etc., causing significant loss to livestock production worldwide.
Surbhi, Nirmal Sangwan, Arun K. Sangwan, Vijender Singh, Ankit Kumar   +4 more
doaj   +1 more source

Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative [PDF]

, 2012
Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.Board of Regents, University of ...
Carney, Darrell H., Fossum, Theresa W., Olszewska-Pazdrak, Barbara   +2 more
core   +1 more source

Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin

Biomolecules, 2019
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova, Valeriia A. Legatova, Rugiya Sh. Alieva, Arthur O. Zalevsky, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov   +6 more
doaj   +1 more source

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay

Frontiers in Pharmacology, 2020
The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders.
Isra Al Zamel, Abdulrasheed Palakkott, Arshida Ashraf, Rabah Iratni, Mohammed Akli Ayoub   +4 more
doaj   +1 more source

TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1

Frontiers in Pharmacology, 2018
Oral blood coagulation inhibitors and their receptors, such as factor Xa (FXa), thrombin, and the thrombin receptor protease-activated receptor 1 (PAR1), are entered into clinical trials for acute coronary syndrome therapy; however, the results obtained ...
Emiko Shinozawa, Masaharu Nakayama, Yoshimi Imura   +2 more
doaj   +1 more source