Results 51 to 60 of about 288,586 (288)
Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury
Frontiers in Pharmacology, 2020 Traumatic brain injury (TBI) commonly leads to development of seizures, accounting for approximately 20% of newly diagnosed epilepsy. Despite the high clinical significance, the mechanisms underlying the development of posttraumatic seizures (PTS) remain
Marina Ben Shimon +7 more
doaj +1 more source
Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells. [PDF]
, 1981 We studied thrombin binding to proliferating and confluent endothelial cells derived from bovine vascular endothelium. [125]thrombin was incubated with nonconfluent or confluent endothelial cells and both the total amount bound and the amount linked in a
Gospodarowicz, D +3 more
core
Journal of Clinical Investigation, 1990 Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To explore potential mechanisms, we set out to determine whether clot-bound thrombin is relatively protected from inhibition by ...
J. Weitz +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 BackgroundThe interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory diseases.
Kerstin Göbel +5 more
doaj +1 more source
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. [PDF]
, 1992 We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that ...
Coughlin, SR +3 more
core +1 more source
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. [PDF]
, 2015 Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling.
Aguilar, Berenice +7 more
core +2 more sources
Blood, 2011 The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible pathogenic mechanism.
F. Semeraro +6 more
semanticscholar +1 more source
The role of atrial natriuretic peptide to attenuate inflammation in a mouse skin wound and individually perfused rat mesenteric microvessels. [PDF]
, 2016 We tested the hypothesis that the anti-inflammatory actions of atrial natriuretic peptide (ANP) result from the modulation of leukocyte adhesion to inflamed endothelium and not solely ANP ligation of endothelial receptors to stabilize endothelial barrier
Adamson, Roger H +5 more
core +2 more sources
Journal of Functional Biomaterials, 2011 Wound healing is a complex series of biochemical and cellular events. Optimally, functional material design addresses the overlapping acute and inflammatory stages of wound healing based on molecular, cellular, and bio-compatibility issues. In this paper
Nicolette Prevost +1 more
doaj +1 more source
Dependence of aptamer activity on opposed terminal extensions : improvement of light-regulation efficiency [PDF]
, 2009 Aptamers that can be regulated with light allow precise control of protein activity in space and time and hence of biological function in general. In a previous study, we showed that the activity of the thrombin-binding aptamer HD1 can be turned off by ...
Buff, Maximilian +6 more
core +2 more sources