Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants.
Cardiovascular Research, 2014 Factor Xa and thrombin are well-known components of the coagulation cascade and have been proven to be viable targets for effective anticoagulation treatment. However, accumulating evidence suggests that these serine proteases are also crucial modulators
H. Spronk +5 more
semanticscholar +1 more source
Application of thrombin powder after tooth extraction in patients receiving anticoagulant therapy [PDF]
Vojnosanitetski Pregled, 2002 Patients with extreme hypocoagulation, which occurs either as an effect of some diseases with coagulation deficiency or because of the anticoagulant therapy (ACT), are a risk group for oral surgery. In the last decades decision to change or interrupt ACT
Marjanović Marjan
doaj +1 more source
Degeneration and regeneration of peripheral nerves: role of thrombin and its receptor PAR-1 [PDF]
, 2017 The peripheral nervous system has a striking regeneration potential and after damage extensive changes in the differentiation state both of the injured neurons and of the Schwann cells are observed.
Artico, M. +7 more
core
Early detection of thrombin activity in neuroinflammatory disease
Annals of Neurology, 2014 Although multiple sclerosis (MS) has been associated with the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinflammatory lesions is unknown. Using a novel molecular probe, we characterized the activity pattern of
Dimitrios Davalos +12 more
semanticscholar +1 more source
Revista Brasileira de Terapia IntensivaRESUMO Objetivo: Correlacionar os níveis de thrombin activatable fibrinolysis inhibitor no pós-operatório imediato e com 24 horas de pós-operatório com o volume de sangramento tansoperatório.
Wagner Luis Nedel +2 more
doaj +1 more source
Journal of Cardiovascular Pharmacology and Therapeutics, 2012 Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease.
P. J. O'Brien, L. Mureebe
semanticscholar +1 more source
Predicting risks of prothrombotic readiness under COVID-19 using genetic testing
Analiz Riska Zdorovʹû, 2023 COVID-19 poses a significant hazard as regards decompensation of underlying chronic diseases, specific damage to the cardiovascular system, and a high risk of negative health outcomes such as thrombotic events.
N.A. Vorobyeva +2 more
doaj +1 more source
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression
Frontiers in Molecular Biosciences, 2023 Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti ...
Cierra A. Birch +6 more
doaj +1 more source
Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]
, 2017 Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura +5 more
core +1 more source
Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests
Hepatology, 2005 The role played by coagulation defects in the occurrence of bleeding in cirrhosis is still unclear. This is partly due to the lack of tests that truly reflect the balance of procoagulant and anticoagulant factors in vivo.
A. Tripodi +6 more
semanticscholar +1 more source