Results 1 to 10 of about 100,897 (348)

Thrombin Generation in Zebrafish Blood. [PDF]

PLoS ONE, 2016
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential.
Evelien Schurgers, Martijn Moorlag, Coenraad Hemker, Theo Lindhout, Hilde Kelchtermans, Bas de Laat   +5 more
doaj   +6 more sources

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal   +6 more
doaj   +2 more sources

The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models [PDF]

Scientific Reports, 2023
Baboon models are often used to investigate haemostatic diseases, such as acquired thrombotic thrombocytopenic purpura or bacterial sepsis-induced disseminated intravascular coagulation, and their potential treatment with novel drugs. Thrombin generation
J. Joubert, S. M. Meiring, W. J. Janse van Rensburg   +2 more
doaj   +2 more sources

Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study [PDF]

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma.
Michael J. Ferrara, Taleen A. MacArthur, Saulius Butenas, Kenneth G. Mann, Joseph M. Immermann, Grant M. Spears, Kent R. Bailey, Rosemary A. Kozar, Stephanie F. Heller, Erica A. Loomis, Daniel Stephens, Myung S. Park   +11 more
doaj   +2 more sources

Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson   +5 more
doaj   +2 more sources

Elevated tissue factor pathway inhibitor delays thrombin generation in COVID-19 but is not associated with clinical outcomes [PDF]

Blood Vessels, Thrombosis & Hemostasis
: Plasma levels of tissue factor pathway inhibitor (TFPI) are elevated in many patients with COVID-19 but the role of TFPI in COVID-19 coagulopathy remains elusive.
Alicia S. Eustes, Meena Kumari Palani Kumar, Julie A. Peterson, Alan E. Mast, Steven R. Lentz, Sanjana Dayal   +5 more
doaj   +2 more sources

The effect of combined oral contraceptives on thrombin generation assessed on ST Genesia– a paired clinical study [PDF]

Thrombosis Journal
Background Treatment with combined oral contraceptives (COC) is associated with an increased risk of venous thromboembolism. Several changes of coagulant and anticoagulant factors induced by ethinyloestradiol during treatment with COC, have been ...
Jesper Strandberg, Inger Lise Gade, Jette Nybo, Janus Nikolaj Laust Thomsen, Søren Risom Kristensen   +4 more
doaj   +2 more sources

Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms. [PDF]

Res Pract Thromb Haemost
Arisz RA, Bakker B, van den Ham R, Ahmed A, Eikenboom JCJ, Schols SEM, de Maat MPM, SYMPHONY consortium@SYMPHONY_NL.   +7 more
europepmc   +3 more sources

Comparative Investigation of Thromboelastometry and Thrombin Generation for Patients Receiving Direct Oral Anticoagulants or Vitamin K Antagonists [PDF]

Diagnostics
Background. Alterations induced by direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) to thromboelastometry and thrombin generation are not well defined.
Armando Tripodi, Marco Capecchi, Erica Scalambrino, Marigrazia Clerici, Barbara Scimeca, Pasquale Agosti, Paolo Bucciarelli, Andrea Artoni, Flora Peyvandi   +8 more
doaj   +2 more sources

Crucial roles of red blood cells and platelets in whole blood thrombin generation. [PDF]

Blood Adv, 2023
Sun S, Campello E, Zou J, Konings J, Huskens D, Wan J, Fernández DI, Reutelingsperger CPM, Ten Cate H, Toffanin S, Bulato C, de Groot PG, de Laat B, Simioni P, Heemskerk JWM, Roest M.   +15 more
europepmc   +3 more sources