Results 11 to 20 of about 47,729 (258)

Platelets and Thrombin Generation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin.
Dougald M, Monroe, Maureane, Hoffman, Harold R, Roberts   +2 more
openaire   +2 more sources

Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]

PLoS ONE, 2016
BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez, Andrey Ziyatdinov, Marina Carrasco, Juan Antonio Millon, Angel Martinez-Perez, Noelia Vilalta, Helena Brunel, Montserrat Font, Anders Hamsten, Juan Carlos Souto, José Manuel Soria   +10 more
doaj   +1 more source

Thrombin generation in the Glasgow Myocardial Infarction Study. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from ...
Machiel Smid, Arne W J H Dielis, Henri M H Spronk, Ann Rumley, Rene van Oerle, Mark Woodward, Hugo ten Cate, Gordon Lowe   +7 more
doaj   +1 more source

Usefulness of Thrombin Generation [PDF]

Hämostaseologie, 2020
AbstractThrombin generation (TG) is a global coagulation procedure meant to continuously monitor thrombin formation and decay upon exposure of platelet-poor plasma to exogenous triggers such as tissue factor, phospholipids, and calcium chloride. The procedure can also be performed in platelet-rich plasma by omitting exogenous phospholipids.
openaire   +2 more sources

Evaluation of the hemostatic potential at coronary artery bypass surgery during long-term aspirin therapy [PDF]

Терапевтический архив, 2016
Aim. To estimate thrombin generation test parameters in patients with coronary heart disease during coronary artery bypass surgery under extracorporeal circulation after transfusion of donor platelet concentrates during long-term therapy with ...
O V Gruzdeva, E V Fanaskova, O E Akbasheva, E G Uchasova, T Yu Penskaya, G P Plotnikov, Yu A Dyleva, K E Krivoshapova, O L Barbarash   +8 more
doaj   +1 more source

Defining the boundaries of normal thrombin generation: investigations into hemostasis. [PDF]

PLoS ONE, 2012
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of
Christopher M Danforth, Thomas Orfeo, Stephen J Everse, Kenneth G Mann, Kathleen E Brummel-Ziedins   +4 more
doaj   +1 more source

Thrombin generation assays: accruing clinical relevance [PDF]

Current Opinion in Hematology, 2004
After decades of near oblivion, thrombin generation is being revived as an overall function test of the plasmatic coagulation system in platelet-poor plasma (PPP). In platelet-rich plasma (PRP) it assesses platelet procoagulant functions as well.The recently developed use of special fluorogenic thrombin substrates allows monitoring of thrombin ...
Hemker, H. Coenraad, Al Dieri, Raed, Beguin, Suzette   +2 more
openaire   +3 more sources

Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

Clinical and Applied Thrombosis/Hemostasis, 2020
We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma,
Mineji Hayakwa MD, PhD, Takayoshi Ooyasu MD, Yoshihiro Sadamoto MD, Tomoyo Saito MD, PhD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD, Masahiro Ieko MD, PhD   +8 more
doaj   +1 more source

In vitro reversal of direct factor Xa inhibitors: Direct comparison of andexanet alfa and prothrombin complex concentrates Cofact and Beriplex/Kcentra

Research and Practice in Thrombosis and Haemostasis, 2022
Background Both andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) are clinically applied reversal agents for direct factor Xa inhibitors (FXaIs) in emergency situations. Controversy exists whether 4F‐PCC is as effective as andexanet
Herm Jan M. Brinkman, Marleen Zuurveld, Joost C. M. Meijers   +2 more
doaj   +1 more source

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting

Cardiovascular Diabetology, 2018
Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer, Thomas Gremmel   +4 more
doaj   +1 more source