Results 191 to 200 of about 47,729 (258)

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, Volume 101, Issue 4, Page 794-806, April 2026.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood. [PDF]

Blood Adv
Wan J, Dhrolia S, Kasthuri RR, Prokopenko Y, Ilich A, Saha P, Roest M, Wolberg AS, Key NS, Pawlinski R, Bendapudi PK, Bendapudi PK, Mackman N, Grover SP.   +13 more
europepmc   +1 more source

Accessing intractable, phosphorylated intrinsically disordered proteins via a protease‐cleavable inclusion body tag

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Phosphorylated intrinsically disordered proteins (IDPs), such as Bcl2‐associated agonist of cell death (BAD) and Tau, play critical roles in apoptosis and neurodegeneration, yet their instability during recombinant expression due to degradation, aggregation, and dephosphorylation, has limited structural and mechanistic studies.
Cat Hoang Vesely, Stanislau Stanisheuski, Edward Lien, Patrick Reardon, Peter J. Chung, Ryan A. Mehl, Richard B. Cooley   +6 more
wiley   +1 more source

In response to bacteria, neutrophils release extracellular vesicles capable of initiating thrombin generation through DNA-dependent and independent pathways. [PDF]

J Leukoc Biol
Whitefoot-Keliin KM, Benaske CC, Allen ER, Guerrero MT, Grapentine JW, Schiff BD, Mahon AR, Greenlee-Wacker MC.   +7 more
europepmc   +1 more source

Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 250-258, April 2026.
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani, Chee Wee Tan, Deborah M. Siegal   +2 more
wiley   +1 more source

Assessment of Platelet Aggregation and Thrombin Generation in Patients with Familial Chylomicronemia Syndrome Treated with Volanesorsen: A Cross-Sectional Study. [PDF]

Biomedicines
Calcaterra IL, Santoro R, Vitelli N, Cirillo F, D'Errico G, Guerrino C, Cardiero G, Di Taranto MD, Fortunato G, Iannuzzo G, Di Minno MND.   +10 more
europepmc   +1 more source

The Secretome From Mechanically Loaded Myoblasts Enhances Tenocyte‐Mediated Wound Healing in a 3D In Vitro Tendon Model

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Human primary myoblasts were subjected to 2% or 10% static mechanical loading for 24 h, with unloaded cells as controls. Conditioned media were collected and applied, together with normal medium, to a 3D tendon fibrin gel model. Secretome from loaded myoblasts, particularly 2% loading, enhanced tenocyte proliferation, scleraxis (SCX) expression, and ...
Junhong Li, Paula Milena Giraldo‐Osorno, Christer Thomsen, Pernilla Eliasson, Ludvig J. Backman   +4 more
wiley   +1 more source

Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII. [PDF]

Res Pract Thromb Haemost
Lamoine S, Jury V, Fourneyron V, Douxfils J, Teissandier D, Talon L, Sinegre T, Lebreton A.   +7 more
europepmc   +1 more source

Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley   +1 more source

Houston, we have a problem: Coagulation concerns during long‐term spaceflight

Experimental Physiology, EarlyView.
Lewis Fall, Damian M. Bailey
wiley   +1 more source