Results 21 to 30 of about 47,729 (258)

Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity. [PDF]

PLoS ONE, 2011
Pre-eclampsia is a complication of pregnancy associated with activation of coagulation. It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could
Chris Gardiner, Dionne S Tannetta, Carol A Simms, Paul Harrison, Christopher W G Redman, Ian L Sargent   +5 more
doaj   +1 more source

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis. [PDF]

PLoS ONE, 2016
Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis.
Patrick Horn, Gülsüm Erkilet, Verena Veulemans, Patric Kröpil, Leon Schurgers, Tobias Zeus, Christian Heiss, Malte Kelm, Ralf Westenfeld   +8 more
doaj   +1 more source

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +1 more source

The in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation

Scientific Reports, 2021
Dabigatran interferes with many coagulation tests. To overcome this obstacle the use of idarucizumab as an in vitro antidote to dabigatran has been proposed.
Mojca Božič Mijovski, Rickard E. Malmström, Nina Vene, Jovan P. Antovic, Alenka Mavri   +4 more
doaj   +1 more source

The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models

Scientific Reports, 2023
Baboon models are often used to investigate haemostatic diseases, such as acquired thrombotic thrombocytopenic purpura or bacterial sepsis-induced disseminated intravascular coagulation, and their potential treatment with novel drugs. Thrombin generation
J. Joubert, S. M. Meiring, W. J. Janse van Rensburg   +2 more
doaj   +1 more source

Follow-up of thrombin generation after prostate cancer surgery: global test for increased hypercoagulability. [PDF]

PLoS ONE, 2012
Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these ...
Matyas Benyo, Tibor Flasko, Zsuzsanna Molnar, Adrienne Kerenyi, Zoltan Batta, Tamas Jozsa, Jolan Harsfalvi   +6 more
doaj   +1 more source

Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study

Haematologica, 2019
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims to explore the relation between thrombin generation and cardiovascular risk factors, cardiovascular diseases, and total mortality ...
Pauline C.S. van Paridon, Marina Panova-Noeva, Rene van Oerle, Andreas Schultz, Iris M. Hermanns, Jürgen H. Prochaska, Nathalie Arnold, Harald Binder, Irene Schmidtmann, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo ten Cate, Philipp S. Wild, Henri M.H. Spronk   +15 more
doaj   +1 more source

Thrombin generation capacity is enhanced by low antithrombin activity and depends on the activity of the related coagulation factors

Thrombosis Journal, 2022
Background Supplementation with antithrombin (AT) concentrates is now common in the treatment of congenital and acquired AT deficiency. However, there is no established consensus on the target and timing of supplementation.
Takumi Tsuchida, Mineji Hayakawa, Shota Kawahara, Osamu Kumano   +3 more
doaj   +1 more source

Recollections on thrombin generation [PDF]

Journal of Thrombosis and Haemostasis, 2008
Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.
openaire   +2 more sources

Thrombin generation in vascular tissue [PDF]

Journal of Thrombosis and Haemostasis, 2006
Classically, it is thought that the vast majority of thrombin is generated on the surface of platelets, however, thrombotic events occur in patients despite treatment with potent antiplatelet agents.In freshly harvested left internal mammary artery (IMA) sections, addition of CaCl2 and platelet-poor plasma (PPP) were sufficient to stimulate a profound ...
A, Pathak, R, Zhao, D M, Monroe, H R, Roberts, B C, Sheridan, C H, Selzman, G A, Stouffer   +6 more
openaire   +2 more sources