Results 31 to 40 of about 100,897 (348)

Trombingenerációs vizsgálatok és klinikai alkalmazásuk [PDF]

, 2014
Thrombin is a key enzyme of the coagulation system, having both pro- And anticoagulant functions. Thus, the generation of thrombin is one of the most important steps in coagulation.
Kern A, Várnai, Katalin, Vásárhelyi, Barna   +2 more
core   +1 more source

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +1 more source

A simplified mathematical model for thrombin generation [PDF]

, 2014
A new phenomenological mathematical model based directly on laboratory data for thrombin generation and having a patient-specific character is described.
Atkin, C., Gavaises, M., Papadopoulos, Konstantinos   +2 more
core   +1 more source

The in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation

Scientific Reports, 2021
Dabigatran interferes with many coagulation tests. To overcome this obstacle the use of idarucizumab as an in vitro antidote to dabigatran has been proposed.
Mojca Božič Mijovski, Rickard E. Malmström, Nina Vene, Jovan P. Antovic, Alenka Mavri   +4 more
doaj   +1 more source

Simulated Thrombin Generation in the Presence of Surface-Bound Heparin and Circulating Tissue Factor [PDF]

, 2015
An expanded computational model of surface induced thrombin generation was developed that includes hemodynamic effects, 22 biochemical reactions and 44 distinct chemical species. Surface binding of factors V, VIII, IX, and X was included in order to more
Chaikof, Elliot L, Dydek, E. Victoria
core   +1 more source

Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation [PDF]

, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which ...
Arachchillage, Deepa RJ, Farag, Mohamed, Gorog, Diana, Gue, Ying X., Lip, Gregory Y H, Spinthakis, Nikolaos, Srinivasan, Manivannan, Wellsted, David   +7 more
core   +3 more sources

Follow-up of thrombin generation after prostate cancer surgery: global test for increased hypercoagulability. [PDF]

PLoS ONE, 2012
Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these ...
Matyas Benyo, Tibor Flasko, Zsuzsanna Molnar, Adrienne Kerenyi, Zoltan Batta, Tamas Jozsa, Jolan Harsfalvi   +6 more
doaj   +1 more source

Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study

Haematologica, 2019
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims to explore the relation between thrombin generation and cardiovascular risk factors, cardiovascular diseases, and total mortality ...
Pauline C.S. van Paridon, Marina Panova-Noeva, Rene van Oerle, Andreas Schultz, Iris M. Hermanns, Jürgen H. Prochaska, Nathalie Arnold, Harald Binder, Irene Schmidtmann, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo ten Cate, Philipp S. Wild, Henri M.H. Spronk   +15 more
doaj   +1 more source

Thrombin generation capacity is enhanced by low antithrombin activity and depends on the activity of the related coagulation factors

Thrombosis Journal, 2022
Background Supplementation with antithrombin (AT) concentrates is now common in the treatment of congenital and acquired AT deficiency. However, there is no established consensus on the target and timing of supplementation.
Takumi Tsuchida, Mineji Hayakawa, Shota Kawahara, Osamu Kumano   +3 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source