Results 51 to 60 of about 100,897 (348)

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study [PDF]

, 2014
Background Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection and asthmatic airway inflammation
Bel, EHD, De Pol, MAV, Johnston, SL, Kamphuisen, PW, Lutter, R, Majoor, CJ, Meijers, JCM, Molenkamp, R, Nieuwland, R, Sterk, PJ, Van der Poll, T, Van der Sluijs, KF, Wolthers, KC   +12 more
core   +7 more sources

Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation. [PDF]

PLoS ONE, 2012
Factor (f)Xa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate ...
Kathleen E Brummel-Ziedins, Thomas Orfeo, Matthew Gissel, Kenneth G Mann, Frits R Rosendaal   +4 more
doaj   +1 more source

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]

, 2017
Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E., Brailoiu, Eugen, Brailoiu, G. Cristina, Shipsky, Megan M., Yan, Guang   +4 more
core   +2 more sources

Thrombin Generation in Plasma: Its Assessment Via the Endogenous Thrombin Potential [PDF]

Thrombosis and Haemostasis, 1995
Thrombin generation is a pivotal function of plasma in haemostasis and thrombosis. Its mechanism is essentially the classical cascade, the velocity of which is governed by the availability of factors Va and VIIIa and that is confined to the surface of the procoagulant membranes which appear at the site of injury.
Hemker, H. Coenraad, Beguin, Suzette
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Abacavir use is associated with increased prothrombin conversion

Frontiers in Immunology, 2023
There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan, Qiuting Yan, Shengshi Huang, Shengshi Huang, Wouter van der Heijden, Marisa Ninivaggi, Lisa van de Wijer, Romy de Laat-Kremers, Andre J. Van der Ven, Bas de Laat, Bas de Laat, Quirijn de Mast   +11 more
doaj   +1 more source

Laboratory Detection of the Antiphospholipid Syndrome via Calibrated Automated Thrombography [PDF]

, 2009
Lupus anticoagulants (LAC) consist of anti phospholipid antibodies, detected via their anti coagulant properties in vitro. Strong LAC relate to thromboembolic events, a hallmark of the anti-phospholipid syndrome.
arnout, jef, Devreese, Katrien, hoylaerts, marc, peerlinck, kathelijne   +3 more
core   +2 more sources

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions.
Ivan D Tarandovskiy, Elena O Artemenko, Mikhail A Panteleev, Elena I Sinauridze, Fazoil I Ataullakhanov   +4 more
doaj   +1 more source