Results 61 to 70 of about 47,729 (258)

Increased In Vivo Thrombin Generation in Patients with Localized Non-Small Cell Lung Cancer Unfit for Surgery

Clinical and Applied Thrombosis/Hemostasis, 2023
Patients with lung cancer face a substantially increased risk of thromboembolic disease. Patients with localized non-small cell lung cancer (NSCLC) who are unfit for surgery due to age or comorbidity have additional thrombotic risk factors.
Johanne Andersen Hojbjerg MD, PhD, Kristian Kirkelund Bentsen MD, Pernille Just Vinholt MD, PhD, Olfred Hansen MD, PhD, Stefan Starup Jeppesen MD, PhD, Anne-Mette Hvas MD, PhD   +5 more
doaj   +1 more source

Thrombin generation in acute promyelocytic leukemia [PDF]

Blood, 1984
Six patients with disseminated intravascular coagulation (DIC) in association with acute promyelocytic leukemia (APL) were studied with sensitive radioimmunoassays that are able to quantitate the extent of thrombin generation within the human circulation.
K A, Bauer, R D, Rosenberg
openaire   +3 more sources

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Thrombosis Journal, 2005
Background Thrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows obtaining thrombin generation ...
Leflem Lena, Busson Joël, Depasse François, Gerotziafas Grigoris T, Elalamy Ismail, Samama Meyer M   +5 more
doaj   +1 more source

Thrombin generation in severely obese children [PDF]

Journal of Thrombosis and Haemostasis, 2006
Since changes of hemostatic parameters in obese patients may contribute to the development of cardiovascular disease [1], we investigated whether there is a relationship between obesity in childhood and alterations in thrombin generation (TG). In a recently published pilot study we have shown that severely overweight children after a significantly ...
C, Cimenti, H, Mangge, H, Haidl, D, Zach, W, Muntean   +4 more
openaire   +2 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Thrombin generation in low plasma volumes [PDF]

Thrombosis Journal, 2018
Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.
Saartje Bloemen, Hilde Kelchtermans, H. Coenraad Hemker   +2 more
openaire   +3 more sources

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case–Control Study

Frontiers in Cardiovascular Medicine, 2017
BackgroundIn peripheral arterial disease (PAD), activation of the hemostatic system may contribute to atherosclerosis progression and atherothrombotic events.ObjectiveThis case–control study assesses the overall coagulation status in PAD patients by ...
Marie-Claire F. Kleinegris, Joke Konings, Joke Konings, Jan W. Daemen, Yvonne Henskens, Bas de Laat, Bas de Laat, Henri M. H. Spronk, Arina J. ten Cate-Hoek, Hugo ten Cate   +9 more
doaj   +1 more source

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

Clinical and Experimental Obstetrics & Gynecology, 2020
Despite numerous studies, there is no general agreement on an ideal biomarker for estimating thrombotic risk in pregnant women. However, it is accepted that the analysis of thrombin generation assesses the coagulation state more accurately compared to ...
R. Mihăilă
doaj   +1 more source