Results 41 to 50 of about 3,126,313 (204)

Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation.

Blood Advances, 2020
Among myeloproliferative neoplasms, polycythemia vera (PV) and essential thrombocythemia (ET) are the 2 entities associated with the most chronic disease course. Leukemic evolution occurs rarely but has a grim prognosis.
D. Luque Paz, Rébecca Jouanneau-Courville, J. Riou, J. Ianotto, F. Boyer, A. Chauveau, Maxime Renard, J. Chomel, E. Cayssials, M. Gallego-Hernanz, C. Pastoret, A. Murati, F. Courtier, M. Rousselet, I. Quintin-Roué, L. Cottin, C. Orvain, S. Thépot, J. Chrétien, Y. Delneste, N. Ifrah, O. Blanchet, M. Hunault-Berger, E. Lippert, V. Ugo   +24 more
semanticscholar   +1 more source

A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family

Haematologica, 2008
Background Hereditary thrombocythemia is an autosomal dominant disorder with clinical features resembling sporadic essential thrombocythemia.
Kun Liu, Robert Kralovics, Zbigniew Rudzki, Barbara Grabowska, Andreas S. Buser, Damla Olcaydu, Heinz Gisslinger, Ralph Tiedt, Patricia Frank, Krzysztof Okoñ, Anthonie P.C. van der Maas, Radek C. Skoda   +11 more
doaj   +1 more source

A Case of Symptomatic Intraluminal Internal Carotid Artery Thrombus in a Patient with Essential Thrombocythemia Surgically Treated by CEA

Case Reports in Neurological Medicine, 2023
We report a patient with a symptomatic intraluminal internal carotid artery thrombus clinically revealed by cerebral infarction. In the preoperative evaluation, it was revealed that essential thrombocythemia existed in the background.
Satoshi Takahashi, Masahiro Katsumata, Hirotsugu Nogawa, Kento Takahara, Jin Nakahara, Masahiro Toda   +5 more
doaj   +1 more source

Interferon alpha therapy in essential thrombocythemia and polycythemia vera - a systematic review and meta-analysis

Leukemia, 2020
Data on the efficacy and safety of interferon (IFN)-α for the treatment of essential thrombocythemia (ET) and polycythemia vera (PV) are inconsistent.
J. Bewersdorf, S. Giri, Rong Wang, N. Podoltsev, Robert T. Williams, M. Tallman, R. Rampal, A. Zeidan, M. Stahl   +8 more
semanticscholar   +1 more source

Familial Essential Thrombocythemia Associated with MPL W515L Mutation in Father and JAK2 V617F Mutation in Daughter

Case Reports in Hematology, 2014
Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report two patients—father and daughter—with essential thrombocythemia who displayed a heterogeneous ...
Adrian P. Trifa, Andrei Cucuianu, Radu A. Popp   +2 more
doaj   +1 more source

Essential thrombocythemia: a rare disease in childhood

Revista Brasileira de Hematologia e Hemoterapia, 2013
Essential thrombocythemia is an acquired myeloproliferative disorder characterized by the proliferation of megakaryocytes in bone marrow, leading to a persistent increase in the number of circulating platelets and thus increasing the risk for thrombotic ...
Julia Maimone Beatrice, Marlene Pereira Garanito   +1 more
doaj   +1 more source

First successful pregnancy outcome after intrauterine insemination in a woman with primary infertility and essential thrombocythemia treated with interferon-alpha and aspirin [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
Introduction. The management of pregnancy in young women with essential thrombocythemia is complex and may present a difficult problem. An adverse pregnancy outcome due to thrombosis or bleeding is a common complication.
Leković Danijela, Gotić Mirjana, Ljubić Aleksandar   +2 more
doaj   +1 more source

Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia.

Blood Advances, 2020
Thrombosis is a major cause of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET). The pathophysiology of thrombosis in these disorders remains unclear, and we hypothesized that upregulation of thrombotic, inflammatory ...
R. Gangaraju, Jihyun Song, Soo Jin Kim, T. Tashi, B. Reeves, K. Sundar, P. Thiagarajan, J. Prchal   +7 more
semanticscholar   +1 more source

Role of blood cells dynamism on hemostatic complications in low-risk patients with essential thrombocythemia [PDF]

, 2015
Patients with essential thrombocythemia (ET) aged less than 60 years, who have not suffered a previous vascular event (low-risk patients), may develop thrombotic or hemorrhagic events.
Bassan, Renato, Bertozzi, Irene, Bl\uf6chl, Elisabeth Maria, Cortelazzo, Sergio, Corvetta, Daisy, De Biasi, Ercole, Elli, Elena, Gastl, G\ufcnther, Gherlinzoni, Filippo, Gottardi, Michele, Guella, Anna, Innella, Barbara, Krampera, Mauro, Marabese, Alessandra, Marcheselli, Luigi, Mitterer, Manfred, Pacquola, Enrica, Perbellini, Omar, Piccin, Andrea, Pizzolo, Giovanni, Pogliani, Enrico Maria, Pusceddu, Irene, Randi, Maria Luigia, Rocconi, Roberta, Sancetta, Rosaria, Steurer, Michael, Tiribelli, Mario, Veneri, Dino, Vivaldi, Paolo   +28 more
core   +1 more source

A risk of essential thrombocythemia in carriers of constitutional CHEK2 gene mutations

Haematologica, 2012
Germline mutations of the CHEK2 gene have been reported in some myeloid and lymphoid malignancies, but their impact on development of essential thrombocythemia has not been studied.
Hanna Janiszewska, Aneta Bąk, Maria Pilarska, Marta Heise, Anna Junkiert-Czarnecka, Małgorzata Kuliszkiewicz-Janus, Małgorzata Całbecka, Bożena JaŸwiec, Dariusz Wołowiec, Kazimierz Kuliczkowski, Olga Haus   +10 more
doaj   +1 more source