Results 11 to 20 of about 28,500 (228)
HSP70 governs permeability and mechanotransduction in primary human endothelial cells. [PDF]
FEBS Open BioHSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Pinto-Martinez A +5 more
europepmc +2 more sources
Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast [PDF]
, 2015 Background: Metastases to the breast from extramammary malignancies are very rare, and ruling out the diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.
Derme, Martina +5 more
core +2 more sources
Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study. [PDF]
, 2015 Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models of ischemia reperfusion injury and sepsis. There are limited data on markers of endothelial dysfunction in human AKI. We hypothesized that Protein C (PC)
Berg, David T +10 more
core +3 more sources
Critical Care, 2019 Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin ...
Takashi Ito +4 more
doaj +1 more source
Haematologica, 2008 Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis +6 more
doaj +1 more source
Thrombomodulin activation driven by LXR agonist attenuates renal injury in diabetic nephropathy
Frontiers in Medicine, 2023 ObjectiveInflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process.
Wei Wang +10 more
doaj +1 more source
Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]
, 2006 Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core +2 more sources
Placental thrombomodulin expression in recurrent miscarriage
Reproductive Biology and Endocrinology, 2010 Background Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it'
Turi Angelo +6 more
doaj +1 more source
Critical Care, 2021 Background A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction.
Daisuke Kudo +7 more
doaj +1 more source
Fujita Medical Journal, 2023 Objectives: Sepsis is a life-threatening condition characterized by multi-organ dysfunction due to host immune system dysregulation in response to an infection.
Tatsuhiko Harada +7 more
doaj +1 more source