Results 51 to 60 of about 28,500 (228)

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis [PDF]

, 2014
Background Parenterally administered ascorbic acid modulates sepsis-induced inflammation and coagulation in experimental animal models. The objective of this randomized, double-blind, placebo-controlled, phase I trial was to determine the safety of ...
Aamer A Syed, Alpha A Fowler, Bernard J Fisher, Christine A Farthing, Christine DeWilde, Don Farthing, Donald F Brophy, Erika Martin, null null, Ramesh Natarajan, Robin Sculthorpe, Seema Gupta, Shelley Knowlson, Terri L Larus   +13 more
core   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. [PDF]

, 2002
The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin.thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential
Crawley, JT, Esmon, CT, Ferrell, G, Gu, JM   +3 more
core  

Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism [PDF]

, 2011
BACKGROUND: The fibrinolytic and matrix metalloproteinase (MMP) systems cooperate in thrombus dissolution and extracellular matrix proteolysis. The plasminogen/plasmin system activates MMPs, and some MMPs have been involved in the dissolution of fibrin ...
Angles-Cano, E. (Eduardo), Barrenetxe, J. (Jaione), Birkland, T.P. (T.P.), Martinez-de-Lizarrondo, S. (Sara), Orbe, J. (Josune), Orset, C. (C.), Paramo, J.A. (José Antonio), Parks, W.C. (W.C.), Purroy, A. (A.), Rodriguez, J.A. (José Antonio), Serrano, R. (Rosario), Vivien, D. (D.)   +11 more
core   +1 more source

Gossypiboma‐associated sarcomas in five cases

Journal of Small Animal Practice, EarlyView.
Objectives To report clinical presentation, treatment and outcome of dogs and cats diagnosed with gossypiboma‐associated sarcoma. Materials and Methods Referral centres within the United Kingdom, Europe, North America and Australia were contacted to search medical records for dogs and cats with documented gossypiboma‐associated sarcoma and included if ...
G. Thomas, L. Doeven, A. Guillén, D. Brockman, E. Herbert, S. Priestnall, J. Helm, K. Shimura, M. Simpson   +8 more
wiley   +1 more source

The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

Nature Communications, 2019
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via ...
C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi   +13 more
doaj   +1 more source

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo, Aziz, Borissoff, Brill, Brinkmann, Clark, Esmon, Esmon, Fuchs, Fuchs, Gladysheva, Gleber, Guthold, Komissarov, Komorowicz, Longstaff, Longstaff, Massberg, Nikolova, Rocha, Ruf, Ryan, Rábai, Rácz, Saha, Sands, Scrutton, Semeraro, Silva, Smeeth, Walker, Weisel, Weisel, Wohner, Xu, Yang, Yeromonahos   +36 more
core   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

Endothelial thrombomodulin—Its role in trauma‐induced coagulopathy

Transfusion, EarlyView.
Abstract Background Trauma‐induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin‐protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes.
Jeries Abu‐Hanna, Gael B. Morrow, Gang Xu, Lewis Timms, Naveed Akbar, Michael Laffan, Robin P. Choudhury, Nicola Curry   +7 more
wiley   +1 more source

The Role of Thrombomodulin in Estrogen-Receptor-Positive Breast Cancer Progression, Metastasis, and Curcumin Sensitivity

Biomedicines, 2023
Estrogen and estrogen receptors (ER) play a key role in breast cancer progression, which can be treated with endocrine therapy. Nevertheless, resistance to endocrine therapies is developed over time.
Chien-Yu Huang, Po-Li Wei, G. M. Shazzad Hossain Prince, Uyanga Batzorig, Cheng-Chin Lee, Yu-Jia Chang, Chin-Sheng Hung   +6 more
doaj   +1 more source