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Effects of Phospholipase A2 Receptor and Thrombospondin Type-1 Domain-Containing 7A Expression in Glomerular Basement Membranes on Treatment Response and Renal Outcome in Membranous Nephropathy

Clinical and Experimental Nephrology, 2021
The aim of this study was to define the clinicopathologic features of phospholipase A2 receptor (PLA2R) and/or thrombospondin type-1 domain-containing 7A (THSD7A) associated membranous nephropathy(MN) focusing on their impact to disease relapse and response to treatment.A total of 201 patients were enrolled for baseline clinical and histopathological ...
Betül Öğüt, Hasan Haci Yeter, Galip Güz   +2 more
exaly   +6 more sources

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Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

New England Journal of Medicine, 2015
Tobias B Huber, Rolf A K Stahl, Florian Grahammer   +2 more
exaly   +5 more sources

Membranous Nephropathy With an Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in a Pregnant Woman

Internal Medicine, 2016
A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, her urine protein became negative.
Takamasa Iwakura, Sayaka Ishigaki, Takayuki Tsuji   +2 more
exaly   +5 more sources

Fibroblast Growth Factor-2 Binding to the Thrombospondin-1 Type III Repeats, a Novel Antiangiogenic Domain

International Journal of Biochemistry and Cell Biology, 2008
Thrombospondin-1, an antiangiogenic matricellular protein, binds with high affinity to the angiogenic fibroblast growth factor-2, affecting its bioavailability and activity.
Raffaella Giavazzi, Giulia Taraboletti, Marco Rusnati   +2 more
exaly   +2 more sources

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

2023
Abstract Thrombospondin type-1 domain-containing 7A (THSD7A) is a large extracellular protein that is found in podocyte foot processes of the kidney glomerulus. It has been established as a causative autoantigen in membranous nephropathy.
Alice Bochel, Simon A. Mortensen, Larissa Seifert, Felicitas E. Hengel, Cy M. Jeffries, Grzegorz Chojnowski, Oliver Kretz, Tobias B. Huber, Nicola M. Tomas, Matthias Wilmanns   +9 more
openaire   +1 more source

Association of the Formiminotransferase N-Terminal Sub-Domain Containing Gene and Thrombospondin, Type 1, Domain-Containing 7A Gene With the Prevalence of Vertebral Fracture in 2427 Consecutive Autopsy Cases [PDF]

Journal of Human Genetics, 2013
We previously reported 2 osteoporosis-susceptibility genes--formiminotransferase N-terminal sub-domain containing gene (FONG) and thrombospondin, type 1, domain-containing 7A (THSD7A)--in which we identified two common single-nucleotide polymorphisms, rs7605378 (FONG) and rs12673692 (THSD7A).
Noriyuki Fuku, Naoko Honma, Shirō Ikegawa   +2 more
exaly   +3 more sources

Features of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A in malignancy-associated membranous nephropathy

Journal of Clinical Pathology, 2019
Aims Phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as pathogenic antigens in patients with membranous nephropathy (MN). Notably, PLA2R is detected in few patients with malignancy-associated MN, and a high incidence of cancer is reported in patients with
Changming Zhang, Mingchao Zhang, Dacheng Chen, Qiang Ren, Weiwei Xu, Caihong Zeng, Weisong Qin, Zhihong Liu   +7 more
openaire   +2 more sources

Circulating antibodies against M-type phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A in Chinese patients with membranous nephropathy

International Urology and Nephrology, 2019
M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) have recently been identified as target antigens for patients with idiopathic membranous nephropathy (IMN). The prevalence of PLA2R and THSD7A in the serum of MN patients deserves further investigation.Here, we studied the presence of anti-PLA2R and anti ...
Caixia, Tian, Lian, Li, Tanxin, Liu, Xin, Qu, Yurong, Qiu   +4 more
openaire   +2 more sources

M-type Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy

2016
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in Caucasians adults. It is defined by the presence of subepithelial immune deposits localized between the podocyte and the glomerular basement membrane (GBM) on electron microscopy examination (EM).
Laurence H. Beck, Sanjeev Sethi, Fernando C. Fervenza   +2 more
openaire   +1 more source

Clinical significance of M-type phospholipase A2 receptor and thrombospondin Type 1 domain-containing 7A in primary membranous nephropathy.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2020
To evaluate the value of thrombospond in Type I domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R) in primary membranous nephropathy (PMN) and to explore the relationship between their antibody levels and prognosis.Renal tissues in 128 patients with membranous nephropathy in the Second Xiangya Hospital of Central South ...
Zailiang, Gong, Shuguang, Yuan, Xuejing, Zhu, Youliang, Wang, Fang, Yu, Danyi, Yang, Xiangqing, Xu, Hong, Liu, Jun, Li, Lin, Sun   +9 more
openaire   +1 more source