Results 1 to 10 of about 1,835 (171)
THSD7A As a Novel Prognostic Factor for Colorectal Carcinoma [PDF]
BMC GastroenterologyBackground Thrombospondin type 1 domain-containing 7 A (THSD7A) expression, an angiogenesis-related protein, has been implicated in various aspects of cancer progression, reflecting its potential as a prognostic marker for various cancers.
Meral Üner +2 more
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THSD7A Positivity Is Associated With High Expression of FAK in Prostate Cancer [PDF]
Diagnostics, 2023 Prostate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner.
Matthias Saar, Rainer Maria Böhle
exaly +7 more sources
Functional characterization of podocyte-expressed THSD7A in experimental membranous nephropathy [PDF]
JCI InsightAlthough the pathogenic role of autoantibodies targeting the podocyte protein THSD7A in membranous nephropathy (MN) is well described, the consequences of autoantibody binding for podocyte homeostasis and the function of THSD7A remain unclear.
Ming Huang +15 more
doaj +4 more sources
Expression of THSD7A in Neoplasm Tissues and Its Relationship With Proteinuria [PDF]
BMC Nephrology, 2019 Background Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies.
Ping Zhang, Guisen Li, Jiamei Luo
exaly +5 more sources
Turkish Journal of NephrologyBackground: Membranous nephropathy (MN) is a glomerular disease characterized by subepithelial immune complex deposition and proteinuria. While phospholipase A2 receptor (PLA2R1) is the main autoantigen in idiopathic MN, thrombospondin type-1 domain ...
Sonay Temurhan +2 more
exaly +4 more sources
Frontiers in Immunology, 2022 Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury,
Laurence H Beck +2 more
exaly +3 more sources
Secreted exosomes induce filopodia formation [PDF]
eLifeFilopodia are dynamic adhesive cytoskeletal structures that are critical for directional sensing, polarization, cell-cell adhesion, and migration of diverse cell types. Filopodia are also critical for neuronal synapse formation.
Caitlin McAtee +10 more
doaj +2 more sources
Long-term outcomes in primary membranous nephropathy: a Chinese cohort study with novel target antigen [PDF]
Frontiers in ImmunologyBackgroundLong-term antigen-specific data in PMN among Chinese populations remain limited. This study evaluated six target antigens and their clinical significance during extended follow-up.MethodsWe retrospectively analyzed 132 treatment-naïve PMN ...
Ping Guo +13 more
doaj +2 more sources
Concurrent Mantle Cell Lymphoma and Paraneoplastic Membranous Nephropathy [PDF]
Kidney MedicineWe report a rare case of synchronous stage IV mantle cell lymphoma (MCL) and paraneoplastic membranous nephropathy (MN) in a 48-year-old man. The patient presented with a nasopharyngeal mass; biopsy confirmed cyclin D1-positive MCL harboring the CCND1 ...
Daoyuan Lv +7 more
doaj +2 more sources
Frontiers in PharmacologyMembranous nephropathy (MN) continues to be a leading cause of nephrotic syndrome in non-diabetic adults. As a unique subtype in the serology-based classification of MN, thrombospondin type 1 domain containing 7A (THSD7A)-associated MN has attracted ...
Deepak Malhotra, Rujun Gong, Yan Ge
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