THSD7A-associated membranous nephropathy involves both complement-mediated and autonomous podocyte injury [PDF]
Frontiers in PharmacologyMembranous nephropathy (MN) continues to be a leading cause of nephrotic syndrome in non-diabetic adults. As a unique subtype in the serology-based classification of MN, thrombospondin type 1 domain containing 7A (THSD7A)-associated MN has attracted ...
Deepak Malhotra +2 more
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THSD7A as a novel prognostic factor for colorectal carcinoma [PDF]
BMC GastroenterologyBackground Thrombospondin type 1 domain-containing 7 A (THSD7A) expression, an angiogenesis-related protein, has been implicated in various aspects of cancer progression, reflecting its potential as a prognostic marker for various cancers.
Oktay Halit Aktepe +8 more
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THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer
Diagnostics, 2023 Prostate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner.
Matthias Saar
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Expression of THSD7A in neoplasm tissues and its relationship with proteinuria [PDF]
BMC Nephrology, 2019 Background Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies.
Dandan Dong, Jiamei Luo, Ping Zhang
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Characterization of THSD7A-antibodies not binding to glomerular THSD7A in a patient with diabetes mellitus but no membranous nephropathy [PDF]
Scientific Reports, 2021 Membranous nephropathy (MN) is an autoimmune disease caused by autoantibodies against the podocyte antigens phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type 1 domain containing protein 7A (THSD7A) in 80% and 2–3% of patients, respectively ...
Linda Reinhard +8 more
doaj +3 more sources
Clinical Features and Pathology of PLA2R and THSD7A-Associated Membranous Nephropathy: A Single-Center Study from China [PDF]
ImmunoTargets and TherapyYan Pan, Wei Dong Chen, Lei Liu, Huijuan Yang, Baochao Chang, Caixia Cui Department of Nephrology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, People’s Republic of ChinaCorrespondence: Wei Dong Chen, Email cwd2012@163 ...
Baochao Chang
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An update on clinical significance of use of THSD7A in diagnosing idiopathic membranous nephropathy: a systematic review and meta-analysis of THSD7A in IMN [PDF]
Renal Failure, 2018 Background: THSD7A is a new target antigen of idiopathic membranous nephropathy (IMN). Moreover, malignancies are also found in patients with THSD7A-positive membranous nephropathy.
Song Ren +6 more
doaj +4 more sources
Frontiers in Immunology, 2022 Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury,
Tiffany N Caza +2 more
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THSD7A-positive membranous nephropathy after kidney transplantation: A case report
Nefrología (English Edition), 2023 Membranous nephropathy (MN) is a common cause of nephrotic syndrome after kidney transplantation (KT); however, scarce is known regarding post-KT thrombospondin type-1 domain-containing 7A (THSD7A)-positive MN.
Eulàlia Solà-Porta +8 more
doaj +6 more sources
A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy [PDF]
Journal of Immunology Research, 2021 Membranous nephropathy (MN) is an organ-restricted autoimmune disease mainly caused by circulating autoantibodies against podocyte antigens, including the M-type phospholipase A2 receptor (PLA2R) and thrombospondin domain-containing 7A (THSD7A ...
Pingna Zhang +7 more
doaj +4 more sources