Results 41 to 50 of about 1,675 (176)

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis

Diagnostics, 2023
Prostate cancer is one of the most common malignancies worldwide, showing a wide range of clinical behaviors. Therefore, several treatment options arise out of the diagnosis “prostate cancer”. For this reason, it is desirable to find novel prognostic and
Fidelis Andrea Flockerzi, Johannes Hohneck, Matthias Saar, Rainer Maria Bohle, Phillip Rolf Stahl   +4 more
doaj   +1 more source

Mechanisms of Primary Membranous Nephropathy

Biomolecules, 2021
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and one of the leading causes of nephrotic syndrome. The disease exhibits heterogenous outcomes with approximately 30% of cases progressing to end-stage renal disease.
Yan Gu, Hui Xu, Damu Tang
doaj   +1 more source

Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan

Scientific Reports, 2022
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. We previously reported that the prevalence of phospholipase A2 receptor (PLA2R)- and thrombospondin type 1 domain containing 7A (THSD7A)-associated MN patients in Japan is ...
Takamasa Iwakura, Chiemi Ema, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +6 more
doaj   +1 more source

Recurrent membranous nephropathy with a possible alteration in the etiology: a case report

BMC Nephrology, 2021
Background Phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major pathogenic antigens for membranous nephropathy (MN).
Ayumi Matsumoto, Isao Matsui, Keiji Mano, Hitoshi Mizuno, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Kazunori Inoue, Takashi Oki, Tadashi Hanai, Keiko Kojima, Tetsuya Kaneko, Yoshitaka Isaka   +12 more
doaj   +1 more source

Clinical Study of THSD7A, SOD2 and AR Antigens in Idiopathic Membranous Nephropathy [PDF]

, 2021
Abstract Background To explore the expression of THSD7A, SOD2 and AR podocyte antigens in the renal tissue of patients with idiopathic membranous nephropathy (IMN) and its clinical diagnostic value in IMN. Method This study retrospectively collected 150 renal tissue specimens and clinical data of patients undergoing renal biopsy in the ...
Honggang Wang, Tingting Zhao, Jianwei Dong, Yan Zhou, Jing Huang, Caifeng Gao, Lei Chen, Jiatong Li, Rong Wang, Bing Chen   +9 more
openaire   +1 more source

Determination of Anti-Phospholipase A2 and Anti-Thrombospondin Type 1 Domain-Containing Protein 7A in Latin Patients with Membranous Nephropathy

Diagnostics, 2022
Primary membranous nephropathy (MN) is caused by antibodies against podocyte antigens, especially the type M receptor of phospholipase A2 (PLA2R) and thrombospondin type-1 domain containing 7 A (THSD7A).
Ligia C. Battaini, Otavio T. Ranzani, Lia J. Marçal, Leila Antonangelo, Lecticia B. Jorge, Cristiane D. Bitencourt, Victoria Woronik, Denise M. A. Malheiros, Luis Yu   +8 more
doaj   +1 more source

DataSheet_1_The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy.docx

, 2022
Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury,
Tiffany N. Caza (13011024), Dorin-Bogdan Borza (324496), Aaron J. Storey (5796863), Laurence H. Beck (13011027), Pallavi Manral (36241)   +4 more
core   +1 more source

A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy

Glomerular Diseases, 2023
Introduction: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 ...
Sanjana Gupta, Mallory Louise Downie, Chris Cheshire, Stephanie Dufek-Kamperis, Adam Paul Levine, Paul Brenchley, Elion Hoxha, Rolf Stahl, Neil Ashman, Ruth Jennifer Pepper, Sean Mason, Jill Norman, Detlef Bockenhauer, Horia Constantin Stanescu, Robert Kleta, Daniel Philip Gale   +15 more
doaj   +1 more source

PLA2R and THSD7A: Disparate Paths to the Same Disease? [PDF]

Journal of the American Society of Nephrology, 2017
The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular subclasses of this disease. Both proteins are large transmembrane glycoproteins expressed by the podocyte, and both induce IgG4-predominant humoral immune responses
openaire   +2 more sources

Critical evaluation of cancer risks in glomerular disease

Translational Oncology, 2022
The increased cancer incidence in patients with glomerular disease can be secondary to an intrinsic immune dysfunction associated with the disease or/and extrinsic factors, especially immunosuppressants. The treatment for paraneoplastic glomerulopathy is
Zaw Thet, Alfred K. Lam, Dwarakanathan Ranganathan, Soe Yu Aung, Thin Han, Tien K. Khoo   +5 more
doaj   +1 more source