Results 61 to 70 of about 1,675 (176)

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation

Frontiers in Pharmacology, 2022
Purpose: To examine the differences in gene expression between ruptured and non-ruptured nucleus pulposus tissues of the intervertebral discs using gene chip technology.Methods: A total of 8 patients with nucleus pulposus from a lumbar disc herniation ...
Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu   +17 more
doaj   +1 more source

Examples of positive and negative staining for THSD7A, PLA2R, and IgG4.

, 2015
Positive staining for THSD7A (a, b), PLA2R (e, f), and IgG4 (i, j), and negative staining for THSD7A (c, d), PLA2R (g, h), and IgG4 (k, l) are shown.
Hideo Yasuda (710367), Satoshi Baba (540358), Naro Ohashi (168272), Akihiko Kato (798462), Takamasa Iwakura (798461)   +4 more
core   +1 more source

Spontaneous Remission of Late Relapsing Membranous Nephropathy After Previous Immunosuppressant‐Induced Remission: Case Report

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
This is the first detailed report of spontaneous remission of late relapsing membranous nephropathy (MN) after previous immunosuppressant‐induced remission. In March 2004, a 52‐year‐old Hispanic male presented with severe nephrotic syndrome with proteinuria of 13 g/24 h. The workup for infectious and autoimmune diseases was unrevealing.
Yangming Cao, Poorani Gurumallesh Prabu
wiley   +1 more source

Recent Advances in Clinical Diagnosis and Pharmacotherapy Options of Membranous Nephropathy

Frontiers in Pharmacology, 2022
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome among adults, which is the leading glomerular disease that recurs after kidney transplantation. Treatment for MN remained controversial and challenging, partly owing to absence of
Yan-Ni Wang, Hao-Yu Feng, Xin Nie, Ya-Mei Zhang, Liang Zou, Xia Li, Xia Li, Xiao-Yong Yu, Ying-Yong Zhao   +8 more
doaj   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, Volume 8, Issue 12, Page 2115-2127, December 2025.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Membranous nephropathy: Systems biology-based novel mechanism and traditional Chinese medicine therapy

Frontiers in Pharmacology, 2022
Membranous nephropathy (MN) is a renal-limited non-inflammatory autoimmune disease in the glomerulus, which is the second or third main cause of end-stage kidney diseases in patients with primary glomerulonephritis.
Hua Miao, Yamei Zhang, Xiaoyong Yu, Liang Zou, Yingyong Zhao, Yingyong Zhao   +5 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, Volume 15, Issue 11, Page 1738-1761, November 2025.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Genetics of Response to ECT, TMS, Ketamine and Esketamine

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 88-102, October 2025.
ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin, Murat Altinay, Kala Bailey, Mahendra T. Bhati, Brent R. Carr, Susan K. Conroy, Khurshid Khurshid, William M. McDonald, Brian J. Mickey, James W. Murrough, Sean M. Nestor, Thomas Nickl‐Jockschat, Irving M. Reti, Gerard Sanacora, Nicholas T. Trapp, Biju Viswanath, Jesse H. Wright, Peter P. Zandi, James B. Potash   +18 more
wiley   +1 more source

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

eLife, 2020
Retinoic acid-related orphan receptor beta (RORβ) is a transcription factor (TF) and marker of layer 4 (L4) neurons, which are distinctive both in transcriptional identity and the ability to form aggregates such as barrels in rodent somatosensory cortex.
Erin A Clark, Michael Rutlin, Lucia S Capano, Samuel Aviles, Jordan R Saadon, Praveen Taneja, Qiyu Zhang, James B Bullis, Timothy Lauer, Emma Myers, Anton Schulmann, Douglas Forrest, Sacha B Nelson   +12 more
doaj   +1 more source

Entwicklung eines THSD7A-abhängigen Mausmodells der membranösen Glomerulonephritis

, 2020
Die membranöse Glomerulonephritis ist eine Autoimmunerkrankung und die häufigste Ursache des nephrotischen Syndroms im Erwachsenen. Ein Drittel der Patienten entwickelt innerhalb von zehn Jahren eine terminale Niereninsuffizienz.
von Spiegel, Hanning
core