Results 51 to 60 of about 1,675 (176)
Characterization of membranous nephropathy with microspherular deposits
Glomerular Diseases, 2023 Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome in the US. The typical ultrastructural finding is of global uniformly dense subepithelial electron-dense immune complex deposits along glomerular basement membranes ...
Kevin Yi Mi Ren, Jean Hou
doaj +1 more source
PROTEOMICS – Clinical Applications, Volume 20, Issue 4, July 2026.ABSTRACT Background and aims Non‐alcoholic Fatty Liver Disease (NAFLD) affects about a quarter of the world's population. Liver biopsy remains the gold standard for diagnosing the progressive form of NAFLD called Non‐alcoholic Steatohepatitis (NASH) but it is invasive, prone to sampling errors and observer variability, and impractical for widespread ...
Anna Negroni +5 more
wiley +1 more source
Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management
Biomedicines, 2019 The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70&#
Sadiq Mu’azu Maifata +3 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham +4 more
wiley +1 more source
Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy
Frontiers in Immunology, 2018 Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while ...
Franziska von Haxthausen +6 more
doaj +1 more source
Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.ABSTRACT Rotator cuff tear (RCT) is a prevalent age‐related condition whose underlying mechanisms remain poorly understood. This study employed spatial transcriptomics and multiplex immunofluorescence (mIF) to investigate gene expression and spatial heterogeneity in rotator cuff tissues from elderly RCT patients compared to age‐matched controls, aiming
Shiyi Yao +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong +19 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio +13 more
wiley +1 more source
Additional file 1: of Expression of THSD7A in neoplasm tissues and its relationship with proteinuria
, 2019 Table S1. Detailed information about patients with positive urinary protein M, male; F, female. Table S2. Correlation between urinary protein and THSD7A staining intensity of in colorectal cancer group.
Gang Xu (219455) +10 more
core +1 more source
Case Reports in Nephrology, Volume 2026, Issue 1, 2026.Introduction The association between membranous nephropathy (MN) and malignant neoplasms has been extensively studied in recent decades and is well established in the literature. Although PLA2R is the main target antigen in primary MN, there remain uncertainties regarding a possible connection between malignancy and anti‐PLA2R positivity.
Fabiano Bichuette Custodio +5 more
wiley +1 more source