Results 51 to 60 of about 1,835 (171)

PLA2R and THSD7A: Disparate Paths to the Same Disease? [PDF]

Journal of the American Society of Nephrology, 2017
The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular subclasses of this disease. Both proteins are large transmembrane glycoproteins expressed by the podocyte, and both induce IgG4-predominant ...
openaire   +2 more sources

A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy

Glomerular Diseases, 2023
Introduction: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 ...
Sanjana Gupta, Mallory Louise Downie, Chris Cheshire, Stephanie Dufek-Kamperis, Adam Paul Levine, Paul Brenchley, Elion Hoxha, Rolf Stahl, Neil Ashman, Ruth Jennifer Pepper, Sean Mason, Jill Norman, Detlef Bockenhauer, Horia Constantin Stanescu, Robert Kleta, Daniel Philip Gale   +15 more
doaj   +1 more source

Entwicklung eines THSD7A-abhängigen Mausmodells der membranösen Glomerulonephritis [PDF]

, 2020
Die membranöse Glomerulonephritis ist eine Autoimmunerkrankung und die häufigste Ursache des nephrotischen Syndroms im Erwachsenen. Ein Drittel der Patienten entwickelt innerhalb von zehn Jahren eine terminale Niereninsuffizienz.
von Spiegel, Hanning
core  

Critical evaluation of cancer risks in glomerular disease

Translational Oncology, 2022
The increased cancer incidence in patients with glomerular disease can be secondary to an intrinsic immune dysfunction associated with the disease or/and extrinsic factors, especially immunosuppressants. The treatment for paraneoplastic glomerulopathy is
Zaw Thet, Alfred K. Lam, Dwarakanathan Ranganathan, Soe Yu Aung, Thin Han, Tien K. Khoo   +5 more
doaj   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source

Characterization of membranous nephropathy with microspherular deposits

Glomerular Diseases, 2023
Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome in the US. The typical ultrastructural finding is of global uniformly dense subepithelial electron-dense immune complex deposits along glomerular basement membranes ...
Kevin Yi Mi Ren, Jean Hou
doaj   +1 more source

Distinct Complement Activation Profiles Between NELL1‐ and PLA2R‐Associated Membranous Nephropathy: A Clinicopathological and Proteomic Study

Nephrology, Volume 31, Issue 10, October 2026.
We compared the clinicopathological features and complement activation profiles of PLA2R‐associated and NELL1‐associated membranous nephropathy. NELL1‐associated membranous nephropathy was associated with older age, more chronic histologic changes and less glomerular C3 and C4d deposition.
Taihei Suzuki, Kang Dedong, Kunio Kawanishi, Masataka Ueda, Yuki Kajio, Kazuki Kobayashi, Nobuhiro Kanazawa, Mayumi Takahashi‐Kobayashi, Joichi Usui, Masaki Baba, Hirokazu Honda, Kazuho Honda, Masayuki Iyoda   +12 more
wiley   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

Immunohistochemical analysis for thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R).

, 2015
Immunostaining for THSD7A (a, c, e) and PLA2R (b, d, f) in patients with idiopathic membranous nephropathy (a–d) and secondary membranous nephropathy (e, f). Original magnification: ×400.
Hideo Yasuda (710367), Satoshi Baba (540358), Naro Ohashi (168272), Akihiko Kato (798462), Takamasa Iwakura (798461)   +4 more
core   +1 more source