Results 31 to 40 of about 1,835 (171)

The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model. [PDF]

FASEB J
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Zhang M, Chen M, Ge Y, Gunning W, Gong R.   +4 more
europepmc   +2 more sources

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives. [PDF]

Animal Model Exp Med
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Liu Q, Bian H, Liu J, Wu L, Zhang Z, Zhao H, Qin X.   +6 more
europepmc   +2 more sources

The research progress of thrombospondin type-1 domain 7A and its antibodies in idiopathic membranous nephropathy

Linchuang shenzangbing zazhi, 2019
Idiopathicmembranous nephropathy(IMN) is an autoimmune glomerular disease with unknown etiology. Current studies have shown that phospholipase A2 receptor(PLA2R) and thrombospondin type-1 domain 7 A(THSD7A) are closely related to the pathogenesis of IMN.
LI Jun, WANG Yan-yan, CHENG Hong
doaj   +1 more source

Clinical significance of the determination of antibodies to thrombospondin type 1 containing domain 7A (THSD7A) in membranous nephropathy

Терапевтический архив, 2023
Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the ...
Patimat A. Kakhsurueva, Elena S. Kamyshova, Irina N. Bobkova, Ekaterina V. Stavrovskaya, Tatiana E. Rudenko, Elena Y. Andreeva   +5 more
doaj   +1 more source

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2018
Background Thrombospondin type 1 domain–containing 7A (THSD7A) has been identified as a pathogenic autoantigen in membranous nephropathy (MN). However, the THSD7A epitopes targeted by patient autoantibodies are unknown.
Larissa, Seifert, Elion, Hoxha, Anna M, Eichhoff, Gunther, Zahner, Silke, Dehde, Linda, Reinhard, Friedrich, Koch-Nolte, Rolf A K, Stahl, Nicola M, Tomas   +8 more
openaire   +2 more sources

Phenotype-dependent heterogeneity of THSD7A expression in gastric cancer tissue in a patient with THSD7A-associated membranous nephropathy. [PDF]

CEN Case Rep
An 88-year-old Japanese man with benign prostatic hyperplasia was presented to our hospital because of proteinuria and generalized edema. He was diagnosed with nephrotic syndrome and underwent a kidney biopsy, which revealed thickening of the capillary wall, spike formation, and subepithelial deposits, leading to histopathological diagnosis of ...
Minezaki C, Azegami T, Hashiguchi A, Nakayama T, Yoshimoto N, Hishikawa A, Hagiwara A, Hayashi K.   +7 more
europepmc   +3 more sources

Profile of Indian Patients With Membranous Nephropathy

Kidney International Reports, 2020
Introduction: The majority of primary membranous nephropathy (MN) cases are no longer considered idiopathic with the discovery of the podocytic autoantigens: phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain–containing 7A (THSD7A ...
Priyadarsani Subramanian, Hemanth Kumar, Bipin Tiwari, Adarsh Barwad, Soumita Bagchi, Arvind Bagga, Sanjay Kumar Agarwal, Amit Kumar Dinda, Geetika Singh   +8 more
doaj   +1 more source

A membranous nephropathy variant mimicking minimal change disease. [PDF]

J Pathol Clin Res
Abstract This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed ‘MCD‐like MN’. Patients with histologically confirmed MN showing sparse and segmental subepithelial electron‐dense deposits (EDD) but clinically resembling MCD were ...
Pan C, Xiang S, Jiang M, Li Y, Huang B, Ye T, Du Y, Tang X, Yuan Y.   +8 more
europepmc   +2 more sources

Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases

Kidney Medicine, 2021
Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura, Chiemi Ema, Taichi Sato, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +7 more
doaj   +1 more source

DataSheet_1_The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy.docx

, 2022
Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury,
Tiffany N. Caza (13011024), Dorin-Bogdan Borza (324496), Aaron J. Storey (5796863), Laurence H. Beck (13011027), Pallavi Manral (36241)   +4 more
core   +1 more source