Results 11 to 20 of about 1,675 (176)

Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development [PDF]

Developmental Dynamics, 2011
AbstractAngiogenesis is a highly organized process under the control of guidance cues that direct endothelial cell (EC) migration. Recently, many molecules that were initially described as regulators of neural guidance were subsequently shown to also direct EC migration.
May-Su You, Yung-Jen Chuang
exaly   +4 more sources

Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis.

PLoS ONE, 2011
BackgroundThrombospondin type I domain containing 7A (THSD7A) is a novel neural protein that is known to affect endothelial migration and vascular patterning during development.
Meng-Wei Kuo, Chian-Huei Wang, Hsiao-Chun Wu, Shing-Jyh Chang, Yung-Jen Chuang   +4 more
doaj   +4 more sources

A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy [PDF]

Brazilian Journal of Nephrology, 2019
Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of
David Campos Wanderley, Bárbara Dornelas Jones, Fabricio Augusto Marques Barbosa, Stanley de Almeida Araujo   +3 more
doaj   +7 more sources

Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats

The Turkish Journal of Gastroenterology, 2021
Background: Thrombospondin type 1 domain-containing 7A (THSD7A) has emerged as a new potential molecular tool for multiple tumors since that THSD7A was detected to be expressed in various malignant tumor types including colorectal cancer (CRC).
Oktay Halit Aktepe, Taha Koray Sahin, Gurkan Guner, Deniz Can Guven, Haci Hasan Yeter, Olcay Kurtulan, Ibrahim Hanifi Ozercan, Omer Dizdar, Suayib Yalcin   +8 more
doaj   +2 more sources

A novel gene THSD7A is associated with obesity [PDF]

International Journal of Obesity, 2015
Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian
Nizamuddin, S, Govindaraj, P, Saxena, S, Kashyap, M, Mishra, A, Singh, S, Rotti, H, Raval, R, Nayak, J, Bhat, BK, Prasanna, BV, Dhumal, VR, Bhale, S, Joshi, KS, Dedge, AP, Bharadwaj, R, Gangadharan, GG, Nair, S, Gopinath, PM, Patwardhan, B, Kondaiah, P, Satyamoorthy, K, Valiathan, MS, Thangaraj, K   +23 more
openaire   +4 more sources

Differential expression of THSD7A in cancer of the vulva.

, 2021
In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of thrombospondin type 1 domain-containing 7A, encoded by THSD7A, in cancer of the vulva.
Shahan Mamoor
openaire   +3 more sources

Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans

BMC Nephrology, 2021
Background: Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropathy (PMN).
Bingileki F Lwezaula, Oluwatoyin I Ameh, Udeme E Ekrikpo, Francois CJ Botha, Ugochi S Okpechi-Samuel, Nicola Wearne, Pierre Ronco, Aminu K Bello, Ikechi G. Okpechi   +8 more
doaj   +2 more sources

Phenotype-dependent heterogeneity of THSD7A expression in gastric cancer tissue in a patient with THSD7A-associated membranous nephropathy. [PDF]

CEN Case Rep
An 88-year-old Japanese man with benign prostatic hyperplasia was presented to our hospital because of proteinuria and generalized edema. He was diagnosed with nephrotic syndrome and underwent a kidney biopsy, which revealed thickening of the capillary wall, spike formation, and subepithelial deposits, leading to histopathological diagnosis of ...
Minezaki C, Azegami T, Hashiguchi A, Nakayama T, Yoshimoto N, Hishikawa A, Hagiwara A, Hayashi K.   +7 more
europepmc   +3 more sources

Secreted exosomes induce filopodia formation [PDF]

eLife
Filopodia are dynamic adhesive cytoskeletal structures that are critical for directional sensing, polarization, cell-cell adhesion, and migration of diverse cell types. Filopodia are also critical for neuronal synapse formation.
Caitlin McAtee, Mikin R Patel, Daisuke Hoshino, Bong Hwan Sung, Ariana K von Lersner, Mingjian Shi, Nan Hyung Hong, Anna Young, Evan Krystofiak, Andries Zijlstra, Alissa M Weaver   +10 more
doaj   +2 more sources

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology: JASN, 2018
Background Thrombospondin type 1 domain–containing 7A (THSD7A) has been identified as a pathogenic autoantigen in membranous nephropathy (MN). However, the THSD7A epitopes targeted by patient autoantibodies are unknown. Methods We performed an in silico analysis of the THSD7A multidomain
Larissa Seifert, Elion Hoxha, GÜNTHER Zahner   +2 more
exaly   +3 more sources