A novel gene THSD7A is associated with obesity [PDF]
International Journal of Obesity, 2015 Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian
Nizamuddin, S +23 more
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Renal FailureBackground This study aims to investigate the incidence and prognosis of malignancy in individuals with thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy (MN).Methods First, we performed a systematic literature review ...
Qianqian Xu +6 more
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Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. [PDF]
PLoS ONE, 2015 Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were ...
Takamasa Iwakura +4 more
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Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans [PDF]
BMC Nephrology, 2021 Background: Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropathy (PMN).
Bingileki F Lwezaula +8 more
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Glomerular Diseases, 2022 Background IgG4-related disease (IgG4-RD) is a systemic multi-organ inflammatory disorder which affects the kidney 20% of the time. Patients with intrinsic IgG4-related kidney disease (IgG4-RKD) often have tubulointerstitial nephritis (TIN) whereas ...
Ryan Malcolm Hum +4 more
doaj +2 more sources
BMC Nephrology, 2019 Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy.
Shinya Taguchi +5 more
doaj +2 more sources
Meta‐Analysis of the Diagnostic Efficiency of THSD7A‐AB for the Diagnosis of Idiopathic Membranous Nephropathy [PDF]
Global Challenges, 2020 Thrombospondin type I domain‐containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A‐AB) represents a promising biomarker for diagnosis of IMN.
Yipeng Liu +10 more
doaj +3 more sources
Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management
Biomedicines, 2019 The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70&#
Sadiq Mu’azu Maifata +3 more
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Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy [PDF]
Frontiers in Immunology, 2018 Membranous nephropathy (MN) is an autoimmune disease caused by binding of circulating antibodies to podocyte antigens in the kidney. For decades and still today primary MN has been considered to have an unspecified IgG4-driven autoimmune genesis, while ...
Franziska von Haxthausen +6 more
doaj +2 more sources
Family study of bipolar disorder with comorbid anxiety disorder points to THSD7A with possible role of parent‐of‐origin effect [PDF]
PCN ReportsAim The aim of this study was to provide new insights into the genetics of bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders. Methods Structured interviews were conducted with BD patients and their parents.
Hiroaki Maki +8 more
doaj +2 more sources