Renal FailureBackground This study aims to investigate the incidence and prognosis of malignancy in individuals with thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy (MN).Methods First, we performed a systematic literature review ...
Qianqian Xu +6 more
doaj +2 more sources
Meta‐Analysis of the Diagnostic Efficiency of THSD7A‐AB for the Diagnosis of Idiopathic Membranous Nephropathy [PDF]
Global Challenges, 2020 Thrombospondin type I domain‐containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A‐AB) represents a promising biomarker for diagnosis of IMN.
Yipeng Liu +10 more
doaj +3 more sources
Glomerular Diseases, 2022 Background IgG4-related disease (IgG4-RD) is a systemic multi-organ inflammatory disorder which affects the kidney 20% of the time. Patients with intrinsic IgG4-related kidney disease (IgG4-RKD) often have tubulointerstitial nephritis (TIN) whereas ...
Ryan Malcolm Hum +4 more
doaj +2 more sources
Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. [PDF]
PLoS ONE, 2015 Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were ...
Takamasa Iwakura +4 more
doaj +2 more sources
Long-term outcomes in primary membranous nephropathy: a Chinese cohort study with novel target antigen [PDF]
Frontiers in ImmunologyBackgroundLong-term antigen-specific data in PMN among Chinese populations remain limited. This study evaluated six target antigens and their clinical significance during extended follow-up.MethodsWe retrospectively analyzed 132 treatment-naïve PMN ...
Ping Guo +13 more
doaj +2 more sources
BMC Nephrology, 2019 Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy.
Shinya Taguchi +5 more
doaj +2 more sources
Family study of bipolar disorder with comorbid anxiety disorder points to THSD7A with possible role of parent‐of‐origin effect [PDF]
PCN ReportsAim The aim of this study was to provide new insights into the genetics of bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders. Methods Structured interviews were conducted with BD patients and their parents.
Hiroaki Maki +8 more
doaj +2 more sources
Case Report: THSD7A-Positive Membranous Nephropathy Caused by Tislelizumab in a Lung Cancer Patient [PDF]
Frontiers in Immunology, 2021 Immune checkpoint inhibitors (ICIs) became the standard treatment for many different kinds of cancers and can result in a variety of immune-related adverse events (irAEs). IrAEs of kidney are uncommon and consists of different pathology types.
Minjiang Chen +5 more
doaj +3 more sources
THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity [PDF]
Modern Pathology, 2016 Thrombospondin type I domain-containing 7A (THSD7A) is a known antigenic target of autoantibodies leading to primary membranous glomerulopathy and was reported to account for ~10% of phospholipase A2 receptor (PLA2R)-negative membranous glomerulopathy.
Christopher P Larsen +2 more
exaly +3 more sources
Functional characterization of podocyte-expressed THSD7A in experimental membranous nephropathy. [PDF]
JCI InsightHuang M +15 more
europepmc +2 more sources