Results 81 to 90 of about 132,893 (224)

Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice

Journal of Xenobiotics, 2011
Prostanoids are lipid compounds that mediate a variety of physiological and pathological functions in almost all body tissues and organs. Thromboxane (TX) A2 is a powerful inducer of platelet aggregation and vasoconstriction and it has ulcerogenic ...
Ivan Ćavar, Tomislav Kelava, Danijel Pravdić, Filip Čulo   +3 more
doaj   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, Volume 1, Issue 3, Page 91-106, September 2026.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

Cellular Physiology and Biochemistry, 2013
Background/Aims: Platelets are critically important for primary haemostasis and the major players in thrombotic vascular occlusion. Platelets are activated by agonists, such as thrombin and collagen-related peptide as well as second-wave mediators ...
Oliver Borst, Britta Walker, Patrick Münzer, Antonella Russo, Evi Schmid, Caterina Faggio, Boris Bigalke, Stefan Laufer, Meinrad Gawaz, Florian Lang   +9 more
doaj   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

Thromboxane receptor-mediated bronchial and hemodynamic responses in ovine endotoxemia

, 1988
The role of thromboxane A2 in sheep endotoxemia, an animal model of the adult respiratory distress syndrome, was investigated by a combined biochemical and pharmacological approach. Endogenous thromboxane biosynthesis was assessed by gas chromatographic-
P. G. Kuhl, J. R. Snapper, J. E. Loyd, J. M. Bolds, G. A. FitzGerald   +4 more
core   +1 more source

Field‐applicable low‐intensity exercise induces bronchodilation in horses with severe asthma

Equine Veterinary Journal, Volume 58, Issue 5, Page 1445-1453, September 2026.
Abstract Background Airway dysfunction in severe equine asthma (SEA) often results in early retirement or euthanasia of affected horses. Exercise‐induced bronchodilation occurs in horses with SEA after intense treadmill exercise, but the effects of a lighter, field‐applicable, training regimen remain largely unexplored.
Sophie Mainguy‐Seers, Sarah‐Maude Grondin, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Modulatory Efficiency of Vitamin C (Ascorbic Acid) on Collagen-Induced Platelet Aggregation and Dysfunction

Biology, Medicine & Natural Product Chemistry
Platelet aggregation, coagulation, and activation are crucial for hemostasis. Collagen treatment can impair hemostatic processes leading to bleeding disorders like thrombosis; vitamin C may mitigate these effects.  Hence, modulatory efficiency of vitamin
Osah Martins Onwuka, Chukwukadibie Adigwe, Oghenefego Michael Adheke, Chamberlin Jamike Elem, Josiah Soipiriala Hart   +4 more
doaj   +1 more source

Furong Tongmai Capsule Ameliorates Atherosclerosis in ApoE−/− Mice by Modulating Gut Microbiota, Arachidonic Acid Metabolism and Macrophage Polarization

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Furong Tongmai capsule (FRTM) is a traditional Chinese medicine formula with reported lipid‐lowering and anti‐inflammatory activities, but its mechanisms in atherosclerosis (AS) remain unclear. In ApoE−/− mice fed a high‐fat diet, FRTM administration improved serum lipid profiles by reducing total cholesterol, triglycerides and low‐density ...
Shuquan Lv, Hanzhou Li, Yuming Wang, Xiuxiu Sang, Feng Wang, Jing Yang, Lirong Fan, Ziang Ma, Lixin Wang, Yuhong Bian, Huantian Cui   +10 more
wiley   +1 more source

Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells.

PLoS ONE, 2019
Bradykinin (BK) and thromboxane-A2 (TX-A2) are two vasoactive mediators that modulate vascular tone and inflammation via binding to their cognate "class A" G-protein coupled receptors (GPCRs), BK-B2 receptors (B2R) and TX-prostanoid receptors (TP ...
Oula K Dagher, Miran A Jaffa, Aïda Habib, Fuad N Ziyadeh, Ayad A Jaffa   +4 more
doaj   +1 more source

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source