Results 101 to 110 of about 5,098,470 (266)

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh [PDF]

, 2009
The aim was to assess the impact of nutritional status and environmental exposures on infant thymic development in the rural Matlab region of Bangladesh.
Collinson, A. C.,, Collinson, AC, Prentice, AM, Vahter, M.,, Raqib, R, Arifeen, SE, R Raqib, Prentice, A. M.,, SE Moore, Prentice, A M, SE Arifeen, Fulford, AJC, Moore, SE, Moore, Sophie E, AC Collinson, Arifeen, S E, Vahter, M, Y Wagatsuma, Raqib, R.,, Persson, L A, Arifeen, S. E.,, Wagatsuma, Y.,, AJC Fulford, Moore, Sophie E.,, Vahter, M,, Fulford, A J C, Persson, LA, AM Prentice, LÅ Persson, Moore, Sophie E; id_orcid, Fulford, A. J. C.,, Collinson, A C, Persson, Lars-Åke,, Wagatsuma, Y, M Vahter   +34 more
core   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Growth regulation in Hydra. Relationship between epithelial cell cycle length and growth rate [PDF]

, 1984
The relationship between epithelial cell production and growth rate was investigated in Hydra attenuata under different feeding regimes. The increase of epithelial cell number was compared to the duration of the epithelial cell cycle using standard ...
Bosch, Thomas C. G., David, Charles N.
core   +1 more source

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

Increased epithelial-free areas in thymuses with altered EphB-mediated thymocyte–thymic epithelial cell interactions

, 2017
Epithelial-free areas, present in both thymic cortex and medulla, have been studied in WT and EphB-deficient mice that have important alterations in the development of thymic epithelium due to the lack of proper thymocyte–thymic epithelial cell ...
Javier García-Ceca, Garcia-Ceca Hernández, Javier, David Alfaro, Agustín G. Zapata, Montero Herradon, Sara, Alfaro Sánchez, David, Zapata González, Agustín, Sara Montero-Herradón   +7 more
core   +1 more source

Role of regulatory T cells in immune tolerance [PDF]

, 2009
In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Thymic epithelial organoids mediate T-cell development [PDF]

Although the advent of organoids has opened unprecedented perspectives for basic and translational research, immune system-related organoids remain largely underdeveloped. Here, we established organoids from the thymus, the lymphoid organ responsible for
Rousse, Paul, Tillard, Lucie, Blackburn, Catherine Clare, Barthlott, Thomas, Lorenzo-Martín, L. Francisco, Holländer, Georg, Hübscher, Tania, Rouse, Paul, Blackburn, C. Clare, Langer, Jakob J., Lutolf, Matthias P.   +10 more
core   +1 more source