The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density [PDF]
, 2003 Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral intramembrane diffusion of lipids, and have been proposed to participate in the control of epithelial cell proliferation and differentiation.
Balda, MS +5 more
core +1 more source
Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Allergy, EarlyView.ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz +22 more
wiley +1 more source
OVOL2 sustains postnatal thymic epithelial cell identity. [PDF]
Nat Commun, 2023 Zhong X +11 more
europepmc +1 more source
A simple model system enabling human CD34+ cells to undertake differentiation towards T cells [PDF]
, 2013 Channelling the development of haematopoietic progenitor cells into T lymphocytes is dependent upon a series of extrinsic prompts whose temporal and spatial sequence is critical for a productive outcome.
B-Lynch Christopher +11 more
core +2 more sources
Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang +4 more
wiley +1 more source
Intrathymic laminin-mediated interactions: role in T cell migration and development
Frontiers in Immunology, 2015 Intrathymic T cell differentiation is a key process for the development and maintenance of cell-mediated immunity, and occurs concomitantly to highly regulated migratory events. We have proposed a multivectorial model for describing intrathymic thymocyte
Wilson eSavino +4 more
doaj +1 more source
Mathematical modelling of T cell homeostasis [PDF]
, 2010 T cell homeostasis describes the process through which the immune system regulates cell survival, proliferation, differentiation and death to maintain T cell numbers and diversity in a range of different conditions. The aim of this thesis is to better
Bains, I.K.
core
'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells : modulation of the adherens junction complex by ketamine [PDF]
, 2013 Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however,
Claire E Hills +23 more
core +1 more source
Emerging Paediatric Uses of Dupilumab Beyond Approvals
Clinical &Experimental Allergy, EarlyView.Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese +11 more
wiley +1 more source
Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks
Clinical &Experimental Allergy, EarlyView.ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado +11 more
wiley +1 more source