Results 121 to 130 of about 5,098,470 (266)
Thymic epithelial cell culture
, 2002 Cell culture, epithelial cells, thymic epithelial ...
Röpke, Carsten
core +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Immunology, EarlyView.Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos +5 more
wiley +1 more source
Use of organ-culture, irradiation and adoptive-transfer to investigate the role of the xenopus thymus in t lymphocyte development [PDF]
, 1986 This Thesis attempts to develop an amphibian model system for exploring the role of the thymus, particularly its stromal cells, in the acquisition of allotolerance. Inbred, clonal and cytogenetically- marked Xenopus are used in this work.
Russ, Jane Hannah
core
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Thymic stromal factors promoting t-cell leukemia [PDF]
, 2017 T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of T cell precursors that affects mainly children and young adults, disseminates throughout the body invading several organs, and fatal without early diagnosis and appropriate ...
Ghezzo, Marinella Nobre
core
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice.
PLoS BiologyAge-related thymic involution leads to diminished output of naïve T-cells. While this process is suggested to increase the risk of disease severity in the elderly following infection, direct evidence is lacking.
Abigail Morales-Sánchez +13 more
doaj +1 more source
Investigating Thymic Epithelial Cell Diversity Using Systems Biology. [PDF]
J Immunol, 2023 Chiu H, Linsley PS, Ziegler SF.
europepmc +1 more source
Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases
Periodontology 2000, EarlyView.Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach +5 more
wiley +1 more source