Results 141 to 150 of about 5,098,470 (266)

Immunosenescence induced by thymic aging and intervention strategies

生物医学转化
T cells are the key effectors of the adaptive immune response, and their development, selection,and establishment of central tolerance depend on the thymus, a critical immune organ.
Xue Yuzhe, Sun Yue, Liu Guanghui, Qu Jing, Sun Shuhui   +4 more
doaj   +1 more source

Revelations in Thymic Epithelial Cell Biology and Heterogeneity from Single-Cell RNA Sequencing and Lineage Tracing Methodologies. [PDF]

Methods Mol Biol, 2023
Morales-Sanchez A, Shissler SC, Cowan JE, Bhandoola A.   +3 more
europepmc   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways. [PDF]

Front Immunol, 2022
Dong X, Zhang J, Zhang Q, Liang Z, Xu Y, Zhao Y, Zhang B.   +6 more
europepmc   +1 more source

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, Volume 270, Issue 2, Page 211-225, October 2026.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

Dual roles for LUBAC signaling in thymic epithelial cell development and survival. [PDF]

Cell Death Differ, 2021
Jain R, Zhao K, Sheridan JM, Heinlein M, Kupresanin F, Abeysekera W, Hall C, Rickard J, Bouillet P, Walczak H, Strasser A, Silke J, Gray DHD.   +12 more
europepmc   +1 more source

Thymic Involution and Function in People With HIV and General Population Controls: A Cross‐Sectional Analysis From Two Danish Cohort Studies

Aging Cell, Volume 25, Issue 10, October 2026.
Thymic involution, the age‐related replacement of thymic soft tissue by fat, has been linked to immunosenescence and chronic inflammation. Whether HIV infection affects thymic involution remains unclear. We found that people with HIV on long‐term antiretroviral therapy had more thymic tissue than controls, indicating less thymic involution. More thymic
Manon C. Vanbellinghen, Anders Boyd, Andreas Ohrt Johansen, Moises Alberto Suarez‐Zdunek, Andreas Dehlbæk Knudsen, Thomas Skårup Kristensen, Jørgen Tobias Kühl, Per Ejlstrup Sigvardsen, Michael Huy Cuong Pham, Andreas Fuchs Larsen, Klaus Fuglsang Kofoed, Børge Grønne Nordestgaard, Shoaib Afzal, Neeltje Kootstra, Susanne Dam Nielsen, Peter Reiss   +15 more
wiley   +1 more source

The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation. [PDF]

Front Immunol, 2021
Pinheiro RGR, Alves NL.
europepmc   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source