Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]
Frontiers in Immunology, 2018 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi +2 more
exaly +8 more sources
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin [PDF]
Respiratory Research, 2022 Background Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP) could reduce inflammation in ...
Changhui Yu +10 more
doaj +5 more sources
Role of thymic stromal lymphopoietin in allergy and beyond [PDF]
Nature Reviews Immunology, 2023 The cytokine thymic stromal lymphopoietin (TSLP) has pleiotropic functions beyond allergic diseases and T helper 2-type immune responses. Here, the authors highlight the roles of TSLP — beneficial or deleterious — in infectious disease, chronic ...
Risa Ebina-Shibuya, Warren J Leonard
exaly +3 more sources
Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases [PDF]
Frontiers in Immunology, 2021 Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of
Si-Hang Wang, Ya-Gang Zuo
doaj +4 more sources
Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses [PDF]
Mediators of Inflammation, 2022 Thymic stromal lymphopoietin (TSLP), long known to be involved in Th2 response, is also implicated in multiple inflammatory dermatoses and cancers. The purpose of this study was to improve our understanding of the expression of TSLP in the skin of those ...
Si-Zhe Li +4 more
doaj +3 more sources
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion
Science, 2021 Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses that characterize allergic diseases. Choa et al. found that mice engineered to produce elevated TSLP displayed selective white adipose tissue
Ruth Ey Choa +2 more
exaly +4 more sources
Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma. [PDF]
Int J Mol Sci, 2023 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical player in the development and progression of allergy and asthma.
Smolinska S +3 more
europepmc +2 more sources
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]
Nature Communications, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody ...
Kenneth Verstraete +14 more
doaj +4 more sources
Serum thymic stromal lymphopoietin (TSLP) levels in atopic dermatitis patients: a systematic review and meta-analysis. [PDF]
Clin Exp Med, 2023 Thymic stromal lymphopoietin (TSLP) is critical in developing allergic responses, including atopic dermatitis (AD). We systematically reviewed the literature to complete a meta-analysis to quantitatively summarize the levels of serum TSLP in AD.
García-Reyes MM +3 more
europepmc +2 more sources
B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling. [PDF]
Sci Immunol, 2023 Long-lived and high-affinity antibodies are derived from germinal center (GC) activity, but the cytokines that regulate GC function are still being identified.
Domeier PP, Rahman ZSM, Ziegler SF.
europepmc +2 more sources