Results 1 to 10 of about 16,647 (226)
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]
Nature Communications, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody ...
Kenneth Verstraete +14 more
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Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases [PDF]
Frontiers in Immunology, 2021 Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of
Si-Hang Wang, Ya-Gang Zuo
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Thymic stromal lymphopoietin in dermatological diseases
Clinical Dermatology Review, 2020 Thymic stromal lymphopoietin is an epithelial cell-derived cytokine expressed in gut, lungs, skin, and thymus. It affects both the local dermal dendritic cells (DCs) and the circulating myeloid DCs.
Mohamed Ibrahim ElGhareeb
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Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]
Frontiers in Immunology, 2018 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi +14 more
doaj +5 more sources
Thymic stromal lymphopoietin in leukemia: A double-edged sword? [PDF]
Leukemia Research ReportsThymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou +6 more
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Inhibition of thymic stromal lymphopoietin production by FK3453
Journal of Pharmacological Sciences, 2022 To prevent the onset and aggravation of allergic diseases, it is necessary to modulate excessive Th2-type immune responses. It is well accepted that thymic stromal lymphopoietin (TSLP) plays important roles in the change of Th1/Th2 balance to Th2 ...
Ryosuke Segawa +3 more
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Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses [PDF]
Mediators of Inflammation, 2022 Thymic stromal lymphopoietin (TSLP), long known to be involved in Th2 response, is also implicated in multiple inflammatory dermatoses and cancers. The purpose of this study was to improve our understanding of the expression of TSLP in the skin of those ...
Si-Zhe Li +4 more
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Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors [PDF]
Molecules, 2021 Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis.
Hyeji Shin +4 more
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Thymic Stromal Lymphopoietin: To Cut a Long Story ShortSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified.
Katerina Tsilingiri +2 more
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Respiratory Research, 2022 Background Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP) could reduce inflammation in ...
Changhui Yu +10 more
doaj +3 more sources