Results 131 to 140 of about 21,196 (261)

The association between celiac disease and eosinophilic esophagitis in children and adults [PDF]

, 2013
BACKGROUND: An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases. METHODS: All patients in a large Canadian city
Eldon Shaffer, Martin A Storr, Michael J Stewart, Paul L Beck, Stephan J Urbanski   +4 more
core   +2 more sources

Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance T helper 2 (Th2) cells are defined by their ability to produce the hallmark cytokine IL-4. However, to mediate allergic inflammation in tissues, Th2 cells must secrete additional cytokines including IL-13 and IL-5.
S. Ochiai, Ferdinand Jagot, Ryan L. Kyle, Evelyn J Hyde, Ruby White, M. Prout, Alfonso J. Schmidt, H. Yamane, O. Lamiable, G. Le Gros, F. Ronchese   +10 more
semanticscholar   +1 more source

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 782-790, March 2026.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

Hypothetical atopic dermatitis-myeloproliferative neoplasm (AD-MPN) syndrome

Frontiers in Immunology, 2015
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells.
Toshiaki eKawakami, Toshiaki eKawakami, Tomoaki eAndo, Yuko eKawakami   +3 more
doaj   +1 more source

Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin

Molecules, 2019
Physcion is well known for the treatment of carcinoma. However, the therapeutic effect of physcion on atopic dermatitis (AD) through the inhibition of thymic stromal lymphopoietin (TSLP) level remains largely unknown.
P. Moon, Na‐Ra Han, Jin Soo Lee, Sungwei Hong, Min-Sun Yoo, Hyeong-Jin Kim, Ji-Hyeon Kim, Soo-Jin Kang, Hyunwoo Jee, Hyung‐Min Kim, Hyun‐Ja Jeong   +10 more
semanticscholar   +1 more source

Importance of Smell Loss to Patients With Chronic Rhinosinusitis With Nasal Polyps: Options for Management and Recovery

Clinical and Translational Allergy, Volume 16, Issue 2, February 2026.
ABSTRACT Primary diffuse type 2‐dominant chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nasal cavity and paranasal sinuses associated with significant morbidity. Impaired sense of smell is a cardinal symptom of CRSwNP and one of the most burdensome for patients, impacting quality of life, mental health, and even ...
Thomas S. Higgins, Jennifer E. Douglas, Robert C. Kern, James N. Palmer, Sietze Reitsma, Martin Wagenmann, Rhea Goodman, Mark Corbett, Cristina Almansa, Amr Radwan   +9 more
wiley   +1 more source

Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march [PDF]

European Respiratory Review, 2014
It has long been observed that the development of asthma, allergic rhinitis and food allergy are frequently preceded by atopic dermatitis, a phenomenon known as the “atopic march”.
Mei Li
doaj  

Potential Role of Interleukin-25/Interleukin-33/Thymic Stromal Lymphopoietin-Fibrocyte Axis in the Pathogenesis of Allergic Airway Diseases

Chinese Medical Journal, 2018
Objective: Allergic airway diseases (AADs) are a group of heterogeneous disease mediated by T-helper type 2 (Th2) immune response and characterized with airway inflammation and remodeling, including allergic asthma, allergic rhinitis, and chronic ...
Xiu-Juan Yao, Xiao-Fang Liu, Xiang-Dong Wang   +2 more
doaj   +1 more source

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD [PDF]

, 2013
Background In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown ...
Adcock, I, Balbi, B, Barczyk, A, Barnes, PJ, Brun, P, Cappello, F, Caramori, G, Casolari, P, Chung, KF, Contoli, M, Di Stefano, A, Durham, AL, Garofano, E, Padovani, A, Papi, A, Vicari, C, Zanini, A   +16 more
core   +1 more source

Distinguishing Features of ILC2s During Type 2 Immune Responses

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Group 2 innate lymphoid cells (ILC2s) are tissue‐resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections.
Manuel O. Jakob, Patrycja M. Forster, Christoph S. N. Klose   +2 more
wiley   +1 more source